A Study of Use of Autologous Cartilage in Ossicular Reconstruction

Siddappa, Prakash Nagenahlli; Jayakumar, Puneeth Poojar; Jonnalagadda, Dheeraj Kumar

doi:10.1007/s12070-018-1514-1

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…Whether utilized as total or partial ossicular replacement prostheses, cartilage grafts establish a stable connection between the remaining ossicles, thereby facilitating the transmission of sound waves through the middle ear. This application of cartilage in ossicular chain reconstruction represents a significant advancement in restoring auditory function with materials that harmonize seamlessly with the natural environment of the middle ear [ 11 ].…”

Section: Reviewmentioning

confidence: 99%

“…Notable examples of autologous cartilage types employed in otologic procedures include auricular cartilage, valued for its flexibility and curvature-matching properties, and costal cartilage, known for its robustness and suitability for larger grafts. Autologous cartilage is a testament to the field's commitment to personalized and patient-specific solutions, ensuring optimal outcomes in various reconstructive endeavors [ 11 ].…”

Section: Reviewmentioning

confidence: 99%

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Cartilage’s Contribution in Otology: A Comprehensive Review of Its Role in Ear Surgery

Kakkad,

Deshmukh,

Gaurkar

2023

Cureus

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This comprehensive review thoroughly examines the pivotal role of cartilage in otologic surgery, elucidating its multifaceted contributions to both cosmetic and functional outcomes. From reconstructing the external ear to reinforcing the tympanic membrane and restoring the ossicular chain, cartilage emerges as a versatile and resilient biological material with unique properties that make it an invaluable resource for otologic surgeons. The review explores the nuances of cartilage's applications in various surgical contexts, emphasizing its significance in promoting tissue regeneration and healing. The text delves into advancements in tissue engineering, biodegradable scaffolds, and 3D printing technology, pointing toward a future where more precise and personalized interventions may redefine the landscape of otologic surgery. The convergence of these innovations holds the promise of elevating the standard of care, minimizing complications, and improving the quality of life for patients undergoing cartilage-based otologic procedures. This synthesis of current knowledge and future possibilities provides a valuable resource for otologists, surgeons, and researchers in the dynamic field of otology.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Cartilage’s Contribution in Otology: A Comprehensive Review of Its Role in Ear Surgery

Kakkad,

Deshmukh,

Gaurkar

2023

Cureus

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“…In the ossicular chain reconstruction, an artificial ossicle (AO) is installed into the middle ear. The prognosis of hearing recovery is affected by AO variations, including the material characteristics ( Jahnke and Plester, 1981 ; Grote et al, 1986 ; Beutner and Hüttenbrink, 2011 ; Shah et al, 2013 ; Jiang et al, 2017 ; Lahlou et al, 2018 ; Siddappa et al, 2019 ); mounting method ( Fleischer, 1991 ); and the shapes of specific geometries, such as the S-shaped prosthesis ( Seivur et al, 2022 ), ball-type structure ( Stoppe et al, 2017 ; Ren et al, 2020 ), C-shaped Shape memory alloys (SMA) prosthesis ( Latalski et al, 2017 ), the partial ossicular replacement prosthesis (PORP), and the total ossicular replacement prosthesis (TORP) ( Kelly et al, 2003 ). It has been found that some of these materials with low biocompatibility tend to be rejected by the body when they are placed in the middle ear.…”

Section: Introductionmentioning

confidence: 99%

“…It has been found that some of these materials with low biocompatibility tend to be rejected by the body when they are placed in the middle ear. For example, AOs composed of titanium or hydroxyapatite have a relatively high rate of rejection ( Siddappa et al, 2019 ). However, it is possible to realize AOs with high biocompatibility by using autologous bone, such as the auricle or nasal septal cartilage of the patient, or by diverting unnecessary autologous residual ossicles.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is possible to realize AOs with high biocompatibility by using autologous bone, such as the auricle or nasal septal cartilage of the patient, or by diverting unnecessary autologous residual ossicles. Autogenous bone grafting is a beneficial choice for middle-ear reconstruction because it is easy to obtain at the surgical site, is non-toxic, shows a low rate of rejection, and gives good hearing gain ( Siddappa et al, 2019 ). The influence of the geometry ( Koike et al, 2002 ) and physical properties ( Greef et al, 2017 ) of AOs has been numerically studied, but there are no examples of parametric verification of the influence of their geometry from the standpoint of mechanical vibration.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission

Asakura

Ito

Hirabayashi

et al. 2023

Front. Bioeng. Biotechnol.

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Conductive hearing loss is caused by a variety of defects, such as chronic otitis media, osteosclerosis, and malformation of the ossicles. In such cases, the defective bones of the middle ear are often surgically reconstructed using artificial ossicles to increase the hearing ability. However, in some cases, the surgical procedure does not result in increased hearing, especially in a difficult case, for example, when only the footplate of the stapes remains and all of the other bones are destroyed. Herein, the appropriate shapes of the reconstructed autologous ossicles, which are suitable for various types of middle-ear defects, can be determined by adopting an updating calculation based on a method that combines numerical prediction of the vibroacoustic transmission and optimization. In this study, the vibroacoustic transmission characteristics were calculated for bone models of the human middle ear by using the finite element method (FEM), after which Bayesian optimization (BO) was applied. The effect of the shape of artificial autologous ossicles on the acoustic transmission characteristics of the middle ear was investigated with the combined FEM and BO method. The results suggested that the volume of the artificial autologous ossicles especially has a great influence on the numerically obtained hearing levels.

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3D Printing of Bioinspired Biomaterials for Tissue Regeneration

Chang

Zhu

et al. 2020

Adv Healthcare Materials

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Biological systems, which possess remarkable functions and excellent properties, are gradually becoming a source of inspiration for the fabrication of advanced tissue regeneration biomaterials due to their hierarchical structures and novel compositions. It would be meaningful to learn and transfer the characteristics of creatures to biomaterials design. However, traditional strategies cannot satisfy the design requirements of the complicated bioinspired materials for tissue regeneration. 3D printing, as a rapidly developing new technology that can accurately achieve multimaterial and multiscale fabrication, is capable of optimizing the fabrication of bioinspired materials with complex composition and structure. This review summarizes the recent developments in 3D-printed bioinspired biomaterials for multiple tissue regeneration, and especially highlights the progresses on i) traditional bioinspired designs for biomaterials fabrication, ii) biological composition inspired designs for the 3D-printed biomaterials, and iii) biological structure inspired designs for the 3D-printed biomaterials. Finally, the challenges and prospects for the development of 3D-printed bioinspired biomaterials are discussed.

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A Study of Use of Autologous Cartilage in Ossicular Reconstruction

Cited by 5 publications

References 13 publications

Cartilage’s Contribution in Otology: A Comprehensive Review of Its Role in Ear Surgery

Cartilage’s Contribution in Otology: A Comprehensive Review of Its Role in Ear Surgery

Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission

3D Printing of Bioinspired Biomaterials for Tissue Regeneration

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