A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Abstract

Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1 H-NMR, 13 C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pK a values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(pmethoxybenzoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.

Determination of pKa values of some novel benzimidazole salts by using a new approach with 1H NMR spectroscopy

“…Finally, the halfneutralization potential values were determined by drawing the ml (TBAH)-mV graphic, and corresponding pK a values were calculated. [37,38] Results and discussion For the determination of pK a values, some spectroscopic methods such as potentiometric titration, [14] UV-VIS spectroscopy, [15] CE [17] and LC [18] were used. These methods were used commonly because of giving high certainty results, being available commercially and automation concurrency.…”

Use of the sulfide minerals pyrite and chalcopyrite as electrochemical sensors in non-aqueous solutions. The potentiometric titration of weak acids in alcohols

“…Therefore, it is very useful for the titration of weak acids with tetrabutylamonium hydroxide (TBAH) [3] and for differentiating the titration of carboxylic acids and phenol [4][5][6]. Due to its excellent solvent characteristics, fundamental information on acid-base equilibria would be very useful [7][8][9][10][11][12][13].…”

“…Therefore, like tert-butyl alcohol, iso-propyl alcohol is a very useful solvent for the titration of weak acids [3,12], for the determination of many organic compounds [4,9,[16][17][18][19], for the determination of pK a values of azlactone dyes [8] and for the potentiometric titration of some hydroxylated benzoic acids and cinnamic acids [20] using TBAH under a nitrogen atmosphere at 25°C. Aktaş et al [21] conductimetrically and potentiometrically titrated hydroxycinnamic acids using triethylamine and TBAH.…”

Synthesis, Anti-bacterial and Anti-oxidant Properties of Thiadiazaphosphol-2-ones

“…- [1,2,4]triazolo [4,3-d] [1,3,4,2]-thiadiaza-phosphol-2-one derivatives are presently reported. 1,2,4 Triazole derivatives are reported to possess a broad spectrum of biological activities such as systemic pesticides, antifungal/microbial/lukemic/parasitic/viral/inflammatory/ tumor/hypertensive/oxidant and anti-human immunodeficiency virus properties.…”

“…1,2,4 Triazole derivatives are reported to possess a broad spectrum of biological activities such as systemic pesticides, antifungal/microbial/lukemic/parasitic/viral/inflammatory/ tumor/hypertensive/oxidant and anti-human immunodeficiency virus properties. [1][2][3][4][5][6][7][8] They also have hypoglycemic, hypocholesteremic activity. This background prompted synthesis of new thiadiazaphosphol-2-ones as continuation of our work in phosphorus heterocycles.…”