A study on alterations in functional activity in migraineurs during the interictal period

Wu, Lanxiang; Wang, Xuan; Liu, Qian; Chai, Limin; Tian, Sheng; Wu, Wei

doi:10.1016/j.heliyon.2022.e12372

Cited by 8 publications

(5 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The frontal lobe, known for its involvement in complex cognitive behaviors, has been previously strongly linked to migraines (Wang et al., 2016; Wu et al., 2023). The studies included here expand on this understanding by highlighting its crucial role in TTH as well.…”

Section: Discussionmentioning

confidence: 99%

Brain structural and functional abnormalities in patients with tension‐type headache: A systematic review of magnetic resonance imaging studies

Parsaei,

Taebi,

Arvin

et al. 2024

J of Neuroscience Research

View full text Add to dashboard Cite

Tension‐type headache (TTH) stands as the most prevalent form of headache, yet an adequate understanding of its underlying mechanisms remains elusive. This article endeavors to comprehensively review structural and functional magnetic resonance imaging (MRI) studies investigating TTH patients, to gain valuable insights into the pathophysiology of TTH, and to explore new avenues for enhanced treatment strategies. We conducted a systematic search to identify relevant articles examining brain MRI disparities between TTH individuals and headache‐free controls (HFC). Fourteen studies, encompassing 312 diagnosed TTH patients, were selected for inclusion. Among these, eight studies utilized conventional MRI, one employed diffusion tensor imaging, and five implemented various functional MRI modalities. Consistent findings across these studies revealed a notable increase in white matter hyperintensity (WMH) in TTH patients. Furthermore, the potential involvement of the specific brain areas recognized to be involved in different dimensions of pain perception including cortical regions (anterior and posterior cingulate cortex, prefrontal cortex, anterior and posterior insular cortex), subcortical regions (thalamus, caudate, putamen, and parahippocampus), cerebellum in TTH pathogenesis was identified. However, no significant association was established between TTH and intracranial abnormalities or total intracranial volume. In conclusion, these findings support the hypotheses regarding the role of central mechanisms in TTH pathophysiology and offer probable brain regions implicated in these mechanisms. Due to the scarce data on the precise role of these regions in the TTH, further preclinical and clinical investigations should be done to advance our knowledge and enhance targeted therapeutic options of TTH.

show abstract

Section: Discussionmentioning

confidence: 99%

Brain structural and functional abnormalities in patients with tension‐type headache: A systematic review of magnetic resonance imaging studies

Parsaei,

Taebi,

Arvin

et al. 2024

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…The fALFF metric has also been utilized to investigate spontaneous neural activity in other types of headaches, including migraine and cluster headache. In migraineurs, changes in fALFF were observed in the bilateral middle frontal gyrus, left postcentral, and right lingual gyrus [ 39 ], as well as in the left rostral ventromedial medulla, right thalamus, left amygdala, and right angular gyrus [ 40 ]. Patients with migraine without aura exhibited alterations in fALFF in the inferior parietal gyrus, bilateral precentral gyrus, right postcentral gyrus, bilateral supplementary motor areas, bilateral precuneus, and left superior frontal gyrus/medial prefrontal cortex [ 11 ], as well as in the ventral posteromedial thalamus and brainstem [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache

et al. 2023

View full text Add to dashboard Cite

Objective. The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH. Methods. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic brain functional activity between patients with ETTH and HCs were analyzed utilizing the fractional amplitude of low-frequency fluctuation (fALFF) approach. Correlation analyses were performed to examine the relationship between fALFF alterations and clinical characteristics. Results. Compared to HCs, patients with ETTH exhibited increased fALFF in the right posterior insula and anterior insula and decreased fALFF in the posterior cingulate cortex. Moreover, the fALFF in the right anterior insula was negatively correlated with attack frequency in ETTH. Conclusions. This study highlights alterations in the intrinsic brain functional activity in the insula and posterior cingulate cortex in ETTH that can help us understand its neurobiological underpinnings.

show abstract

“…The Mini-Mental State Examination (MMSE)[ 21 ] includes five cognitive aspects: Orientation, memory, attention/computation, memory, and language, with a total score of 30. Scores of less than 24 (> 6 years of education or intermediate or above), 20 (< 6 years of education), and 17 (illiterate) were considered cognitively impaired[ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Differences in insomnia-related self-reported outcomes among elderly hospitalized patients

Ding,

Qi,

Sun

2024

World J Psychiatry

View full text Add to dashboard Cite

BACKGROUND Insomnia is among the most common sleep disorders worldwide. Insomnia in older adults is a social and public health problem. Insomnia affects the physical and mental health of elderly hospitalized patients and can aggravate or induce physical illnesses. Understanding subjective feelings and providing reasonable and standardized care for elderly hospitalized patients with insomnia are urgent issues. AIM To explore the differences in self-reported outcomes associated with insomnia among elderly hospitalized patients. METHODS One hundred patients admitted to the geriatric unit of our hospital between June 2021 and December 2021 were included in this study. Self-reported symptoms were assessed using the Athens Insomnia Scale (AIS), Generalized Anxiety Disorder Scale-7 (GAD-7), Geriatric Depression Scale-15 (GDS-15), Memorial University of Newfoundland Scale of Happiness (MUNSH), Barthel Index Evaluation (BI), Morse Fall Scale (MFS), Mini-Mental State Examination, and the Short Form 36 Health Survey Questionnaire (SF-36). Correlation coefficients were used to analyze the correlation between sleep quality and self-reported symptoms. Effects of insomnia was analyzed using Logistic regression analysis. RESULTS Nineteen patients with AIS ≥ 6 were included in the insomnia group, and the incidence of insomnia was 19% (19/100). The remaining 81 patients were assigned to the non-insomnia group. There were significant differences between the two groups in the GDA-7, GDS-15, MUNSH, BI, MFS, and SF-36 items (P < 0.05). Patients in the insomnia group were more likely to experience anxiety, depression, and other mental illnesses, as well as difficulties with everyday tasks and a greater risk of falling (P < 0.05). Subjective well-being and quality of life were poorer in the insomnia group than in the control group. The AIS scores positively correlated with the GAD-7, GDS-15, and MFS scores in elderly hospitalized patients with insomnia (P < 0.05). Logistic regression analysis showed that GDS-15 ≥ 5 was an independent risk factor for insomnia in elderly hospitalized patients (P < 0.05). CONCLUSION The number of self-reported symptoms was higher among elderly hospitalized patients with insomnia. Therefore, we should focus on the main complaints of patients to meet their care needs.

show abstract

A study on alterations in functional activity in migraineurs during the interictal period

Cited by 8 publications

References 50 publications

Brain structural and functional abnormalities in patients with tension‐type headache: A systematic review of magnetic resonance imaging studies

Brain structural and functional abnormalities in patients with tension‐type headache: A systematic review of magnetic resonance imaging studies

Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache

Differences in insomnia-related self-reported outcomes among elderly hospitalized patients

Contact Info

Product

Resources

About