A Study on Antitubercular and Antimicrobial Activity of Isoniazid Derivative

Abstract

Background: Hydrazones belonging to azomethine class of compounds have attracted the attention of many chemists owing to their wide spectrum of pharmacological activity profile with structural flexibility and ligating behavior. Objectives: We aimed to synthesize a potential ligand containing both, isonicotinoylhydrazide and 3-ethoxy-2-hydroxybenzilidine moieties, linked through azomethine group. Materials and Methods: In this descriptive study, a new ligand derived by the condensation of isonicotinoylhydrazide and 3-ethoxysalicylaldehyde have been synthesized. Ligand was characterized on the basis of various spectroscopic techniques like IR, 1H and 13C NMR studies, elemental analysis. The compound was subjected to antimicrobial and anti-tubercular activity screening using serial broth dilution method and minimum inhibitory concentration (MIC) is determined. The ligand was evaluated for its antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus ATCC 9144) and Gram-negative bacterium (Escherichia coli ATCC 11303). New compound synthesized showed good biological activity against tested bacteria. Furthermore, ligand shows high levels of activity against Mycobacterium tuberculosis (H37RV) in vitro. Results: The elemental analysis, 1H and 13C NMR studies of ligand confirm the formation of title compound with the molecular formula C15H15N3O3. Ligand shows inhibition against mycobacterium at concentration 4 µg/mL. Conclusions: The schiff bases ligand was readily prepared for evaluation against M. tuberculosis in good yield. Compound show good activity in vitro.

Crystal structure and characterization of new cadmium complex from 4-pyridin-carbohydrazide and 2-chlorobenzaldehyde

“…It was proved that isoniazid has also has an anti-depressive effect, one of the first anti depressive drugs discovered. It is also used in a wide range of bacterial diseases [6][7][8][9]. Hydrazones exhibit physiological activities in the treatment of several diseases such as tuberculosis.…”

Synthesis, Characterization and EPR Study of Some Transition Metal Complexes with N-O Donor Lewis Base of Isonozide.

“…The complex of Mn(II) was synthesized following the same procedure in (2)(3)(4)(5), but by using the ratio of 2:1 from ligand to salt. Yield: 75% , m. p.: 257-259 o C.…”

“…Hydrazones are known as compounds containing two interrelated R 1 CN-NR 2 nitrogen atoms, as they could act as antimicrobial, antitubercular and antitumor agents [3][4][5][6]. After the cornerstone of anti-TB therapy has been used for more than half a century, much has been learned about biochemistry and multifaceted ways to act as isoniazid front-line drugs.…”

Solvent Free Synthesis of some Metal Complexes of Novel Ligand Derived from 2-Amino-5, 6-Dimethyl Benzimidazole with 2-Bromo Isophthalaldehyde and Characterization, Biological Activity of Same

“…The products of ketone or aldehyde with primary amine are generally known as Schiff base [7]. They are biologically very active compounds, having biological activities like antibacterial [8], antimicrobial [9], anticancer [10], plant growth inhibitors [11] and so on.…”