A Study on Burden of Carbapenem-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Infections in a Tertiary Care Hospital of Eastern India

Abstract

Introduction: Healthcare associated infections(HAI) by multi-drug resistant organisms(MDRO) are major cause of mortality and morbidity having significant impact on quality of life and economic burden. HAI by carbapenem-resistant Pseudomonas aeruginosa (CRPsA) and Acinetobacter baumannii (CRAB) are emerging threat for their high antibiotic resistance and spread via mobile genetic elements. Objectives of this study were to detect prevalence of CRPsA and CRAB infections in a tertiary care hospital of Eastern India and to determine their antimicrobial resistance profile.

Prevalence of Carbapenem-Resistant Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa in a Tertiary Care Hospital in Eastern India: A Pilot Study

“…In a tertiary care facility in Delhi, Wattal et al reported high carbapenem resistance in Enterobacterales, with a prevalence ranging from 13% to 51%. 17 In our study, the prevalence of CRAB (9.84%) and CRPA (3.16%) which is similar to previous studies by Grewal et al 18 and Bandyopadhyay et al 19 According to Benachinmardi, et al, 20 P. aeruginosa infections were more common, indicating a recent trend towards an increase in A. baumannii infections.…”

Emergence of Extended-Spectrum Beta-Lactamase and Carbapenemase Producing Gram Negative Non-Fermenters at Selected Hospitals of Northeast Ethiopia: A Prospective Cross-Sectional Study

“…38 A. baumannii was predominantly isolated from blood samples (5.2%) followed by sputum (2.1%), wounds (2.1%) and urine (1%) in the present study. This study corroborated a study from India at a tertiary care hospital, 45 and from Madagascar. 7 However; the finding of the…”

“…28 On the other hand, it was lower than a study from Ethiopia, 27 United States, 26 and Latin America. 46 The proportion of carbapenem resistant P. aeruginosa isolates in the present study is consistent with studies done in Egypt, 42 India, 45 and United States. 26 However, it was higher than a study from Ethiopia 27 and Libya (24%).…”

“…The proportion of carbapenem resistant A. baumannii isolates in this study was consistent with a study in eastern India, 45 India, 3 Nepal 7 and Ethiopia, 47 India. 45 However, it was higher than a study from Uganda. 28 On the other hand, it was lower than a study from Ethiopia, 27 United States, 26 and Latin America.…”

“…This is concurrent with the results of studies from Asia. 38,45,46 The predominance of P. aeruginosa in wound infections might be linked to contamination of the wound from health care workers' fomites, hands and hospital environments rather than other site of infections. The current carbapenem resistance rate (66.7%) among non-fermenters is higher than other studies from Ethiopia, 27 Bangladesh (14.5%), 25 and USA (4.5%), 26 This shows the rising prevalence of carbapenem resistance among nonfermenter GNB isolates, which is a threat to clinical practices.…”