Despite widely highlighting that creative individuals need to be full of vitality to function optimally, previous research neglects the very real possibility that human beings may also need to proactively manage their vitality to ignite creativity. Drawing on the conservation of resources theory, this study explores the impact of proactive vitality management on undergraduates’ creativity through harmonious academic passion, as well as the moderating roles of university creative climate and prevention focus. Evidence from a scenario-based experiment (Study 1) and a multi-wave field survey (Study 2) demonstrated that proactive vitality management positively promoted individual creativity. This relationship was partially mediated by harmonious academic passion. In addition, proactive vitality management enhanced undergraduate students’ creativity via harmonious academic passion in a high university creative climate, whereas the indirect effect was weak when prevention focus was high. Theoretical and practical implications are also discussed, along with study limitations and future research directions.