A study on cytocompatible poly(chitosan-g-l-lactic acid)

Yao, Fanglian; Chen, Wei; Wang, Hao; Liu, Haifeng; Yao, Kangde; Sun, Pingchuan; Lin, Hai

doi:10.1016/s0032-3861(03)00676-1

Cited by 105 publications

(79 citation statements)

References 25 publications

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“…These features are characteristic of polysaccharidic structure. Similar results have been reported previously (Sila et al, 2014b;Wu, 2009;Yao et al, 2003). The peak at 3 398 cm -1 represents the stretching of the hydroxyl groups.…”

Section: Methodssupporting

confidence: 91%

Water-soluble polysaccharides from Opuntia stricta Haw. fruit peels: recovery, identification and evaluation of their antioxidant activities

Koubàa¹,

Ktata²,

Barba³

et al. 2015

International Agrophysics

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A b s t r a c t. Opuntia stricta Haw. is considered as one of the most common cactus plant growing in Tunisia. Extracting valuable compounds from its fruit peel, considered as by-product, is drawing more and more attention, making it on the verge of commercialization. Water-soluble polysaccharides were extracted from Opuntia stricta Haw. peels, and their chemical composition assessed using thin layer chromatography. The antioxidant activities of the extracted polysaccharides were assessed using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity, total antioxidant activity and reducing power capacity. The extraction yield of water-soluble polysaccharides was 7.53±0.86%. The chemical composition revealed the presence of rhamnose, arabinose, glucose, mannose, galactose and galacturonic acid. The infra-red spectroscopic analysis showed a similar structure to that of Opuntia ficus-indica polysaccharide peels. Additionally, the extracted polysaccharides exhibited high antioxidant activities. In fact, the free radical scavenging activity (half inhibition concentration = 6.5 mg ml -1 with 94.9% inhibition at 50 mg ml -1

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Section: Methodssupporting

confidence: 91%

Water-soluble polysaccharides from Opuntia stricta Haw. fruit peels: recovery, identification and evaluation of their antioxidant activities

Koubàa¹,

Ktata²,

Barba³

et al. 2015

International Agrophysics

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“…This suggests the presence of free lactic acid in the spray-dried chitosan lactate salt. This finding is also in agreement with earlier works (36). The FTIR spectra of chitosan citrate show Fig.…”

Section: Fourier Transform Infrared Spectroscopysupporting

confidence: 93%

“…As lactic acid reacts with chitosan, it will take place at random along the chitosan chain giving rise to a random copolymer. According to Yao et al, this will destroy regular packing of the original chitosan chains resulting in formation of almost amorphous copolymer (36). After spray drying, halo diffraction patterns of chitosan lactate salt evidenced amorphous state.…”

Section: X-ray Powder Diffractionmentioning

confidence: 99%

“…In the case of chitosan citrate (and use of citric acid), this finding can be attributed to the higher number of carboxylic groups in the molecule of citric acid in relation to the molecule of the other two acids employed, thus allowing a greater ionic interaction with chitosan (28,38). At elevated temperatures, the carboxylic acids may protonate and slowly react with the amine to form an amide (34,36). This amidation decreases the amount of hydrophilic groups and result in lower water sorption (34).…”

Section: Thermal Properties Of Chitosan Saltsmentioning

confidence: 99%

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Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

et al. 2011

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Abstract. The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (Panulirus argus) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS 13 C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state 13 C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm −1 were diminished suggesting that -NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm −1 , respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (P. argus) origin.

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“…Moreover, increasing of polylactic acid (PLA) in the films induced in order to decrease the tensile strength and elongation at break. This is due to the increment of polylactic acid (PLA) concentration, the content of the unreacted monomer and the oligomer also increased, resulting in the deformation of the strong hydrogen bond between the chitosan chains, thus the tensile strength and elongation at break of crude films decreased [11].…”

Section: Response Surface Plotmentioning

confidence: 99%

Optimization of Mechanical Properties of Silver Nanoparticles (AgNPS)-Loaded Chitosan/Polylactic Acid (PLA) Biofilms by Using Response Surface Methodology (RSM)

2017

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Abstract. Fabrication of silver nanoparticles-loaded chitosan-polylactic acid based biofilms was successfully employed for investigating the optimal of mechanical properties (i.e. tensile strength and elongation at break) of biofilms using central composite design (CCD), response surface methodology (RSM). In this study, only two factors that influences the biofilm mechanical properties were selected namely concentration of polyethelene glycol 400 (PEG) and percentage volume of polylactic acid (PLA)/chitosan. Analysis of results was performed by using response surface methodology (RSM) to avoid the traditional one-factor-at-a-time experiments. Common statistical tools such as analysis of variance (ANOVA) and response surface plot were used to determine the optimal tensile strength and elongation at break responses. Central composite design (CCD) builds a response surface for mechanical properties of biofilms optimization. From the results of statistical analysis, it could be concluded that the optimal conditions for mechanical properties of biofilms were 7.93% w/w concentration of polyethylene glycol (PEG) and 28.79%/71.21% percentage volume of polylactic acid (PLA)/chitosan. At this optimum stage, 7.99 MPa of tensile strength and 32.6 % elongation at break were obtained. Then, results of verification process have shown that the percentage errors are 2.08% for tensile strength and 3.89% elongation at break, respectively.

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A study on cytocompatible poly(chitosan-g-l-lactic acid)

Cited by 105 publications

References 25 publications

Water-soluble polysaccharides from Opuntia stricta Haw. fruit peels: recovery, identification and evaluation of their antioxidant activities

Water-soluble polysaccharides from Opuntia stricta Haw. fruit peels: recovery, identification and evaluation of their antioxidant activities

Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

Optimization of Mechanical Properties of Silver Nanoparticles (AgNPS)-Loaded Chitosan/Polylactic Acid (PLA) Biofilms by Using Response Surface Methodology (RSM)

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