A Study on Fabrication of 3D Porous Scaffold Combined with Polymer Deposition System and a Salt Leaching Method

Shim, Hae-Ri; Sa, Min-Woo; Kim, Jong‐Young

doi:10.14775/ksmpe.2016.15.5.086

Cited by 4 publications

(2 citation statements)

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“…In order to solve this problem, the use of a suitable temporary porogen has been reported many times in previous studies 18 . Shim et al 19 have reported that NaCl can be a good porogen in the PCL matrix due to its good solubility in water and nontoxic effect on living cells. In the other study, Guarino et al 20 showed that the yield stress of PCL scaffolds by the addition of NaCl was reduced from 1 to 0.05 MPa for 50% and 91% vol.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

Khodabakhshi,

Soleimanimehr,

Etemadi Haghighi

et al. 2023

Polymer Engineering & Sci

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Segmental bone tissue engineering is a highly effective approach for the repair of large bone defects. In this article, 3D printing was used to fabricate the polycaprolactone (PCL)/NaCl‐based cylindrical structures. The effects of the structure's thickness (L) and NaCl concentration on the mechanical properties, degradability, swelling behavior, porosity, and cytotoxicity of the samples were investigated. Response surface methodology was employed to study the mechanical behavior using the central composite design (CCD). Results showed that increasing the NaCl concentration up to 10% wt significantly improved the degradability, swelling, and hydrophilicity of the structures. It was also indicated that the maximum stiffness of the guide structures under vertical loading was almost five times larger than the horizontal loading direction, but the samples showed greater compressive strength and elongation under horizontal compressive loading. Results indicated that the mechanical properties of the structures were more dependent on the structure thickness so the thicker structures with an 800 μm thickness had better mechanical properties in both vertical and horizontal loading. Cytotoxicity assay also approved the nontoxic effect of the PCL structures on the MC3T3 osteoblast cell line. Based on the results, the PCL‐based structures were a suitable candidate to act as a guide for segmental bone tissue engineering.Highlights A 3D‐printed conduit was manufactured to guide bone reconstruction Response surface methodology (RSM) using central composite design (CCD) was employed NaCl concentration and the diameter of strands were the main parameters This 3D‐printed guiding approach is useful for segmental bone tissue engineering

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Section: Introductionmentioning

confidence: 99%

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

Khodabakhshi,

Soleimanimehr,

Etemadi Haghighi

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

“…In order to solve this problem, the use of a suitable temporary space holder has been reported many times in previous studies (Samuel, Kong et al 2022). Shim et al (Shim, Sa et al 2016) have reported that NaCl can be a good space holder in the PCL matrix due to its good solubility in water and nontoxic effect on the living cells. In the other study, Guarino et al (Guarino, Causa et al 2007), showed that the yield stress of PCL scaffolds by addition of NaCl was reduced from 1 to 0.05 MPa for 50 and 91% vol.…”

Section: Introductionmentioning

confidence: 99%

In-vitro evaluation of PCL-based film for guiding segmental bone defect

Khodabakhshi

Soleimanimehr

Haghighi

et al. 2022

Preprint

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Segmental bone tissue engineering is a highly effective approach for the repair of large bone defects. In this paper, a PCL-based guide film was developed for controlling segmental bone tissue engineering. 3D bioprinting was used to fabricate the PCL/NaCl-based cylindrical films. The effects of the film's thickness and NaCl concentration on the mechanical properties, degradability, swelling behavior, porosity, and cytotoxicity of the samples were investigated. Response surface methodology was employed to study the mechanical behavior using the central composite design (CCD) results showed that increasing the NaCl concentration up to 10% wt. significantly improved the degradability, swelling, and hydrophilicity of the films. It was also indicated that the maximum stiffness of the guide films under vertical loading was almost 5 times more than the maximum stiffness in the horizontal loading direction, but the samples showed greater compressive strength and elongation under horizontal compressive loading. All the evidence indicated that the mechanical properties of the films were more dependent on the film thickness so the thicker films with an 800µm thickness had better mechanical properties in both vertical and horizontal loading. Cytotoxicity assay also approved the non-toxic effect of the PCL films on the MC3T3 osteoblast cell line. Based on the results, the PCL-based films were a suitable candidate to act as a guide for segmental bone tissue engineering.

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Fabrication of 3D PCL/PVP scaffolds using monosodium glutamate as porogen by solvent casting/particulate leaching method for oral and maxillofacial bone tissue engineering

Thai,

Nguyen,

Truong

et al. 2024

Biomed. Mater.

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The design of three-dimensional (3D) scaffolds should focus on creating a highly porous, 3D structures with an interconnected pore network that supports cell growth. The scaffold’s pore interconnectivity is directly linked to vascularization, cell seeding, guided cell migration, and transportation of nutrients and metabolic waste. In this study, different types of food flavors including monosodium glutamate, sugar, and sodium chloride were used as the porogens along with PCL/PVP blend polymer for solvent casting/particulate leaching method. The morphology, porosity, interconnectivity, chemical composition, water absorption, and mechanical properties of the fabricated scaffolds are carefully characterized. The scaffolds are biocompatible in both in vitro and in vivo experiments and do not trigger any inflammatory response, while enhancing new bone formation and vascularization in rabbit calvaria critical‐sized defects. The new bone merge and become denser along with the experiment timeline. The results indicate that the 3D PCL/PVP scaffolds, using monosodium glutamate as porogen, exhibited suitable biological performance and held promise for bone tissue engineering in oral and maxillofacial surgery.

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A Study on Fabrication of 3D Porous Scaffold Combined with Polymer Deposition System and a Salt Leaching Method

Cited by 4 publications

References 0 publications

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

In vitro evaluation of polycaprolactone‐based structure for guiding segmental bone defect

In-vitro evaluation of PCL-based film for guiding segmental bone defect

Fabrication of 3D PCL/PVP scaffolds using monosodium glutamate as porogen by solvent casting/particulate leaching method for oral and maxillofacial bone tissue engineering

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