“…13 However, both hair follicles and sweat ducts have a small surface area, which limits the area that the drug may directly come into contact when administered. 17 Drugs that are hydrophilic may bypass the corneocytes and enter the body through the second route, which is called the transcellular or intracellular route. 16 The last path is intercellular or paracellular, where the medication diffuses across the continuous lipid matrix, therefore being the best way to transport lipophilic substances.…”