The matching between the wire material and the base metal has an extremely important influence on the performance of the welded joint. In this work, the effects of two welding materials THQ440-NQ-II and ER50-6 with different compositions on the microstructure, mechanical properties and corrosion resistance of bridge weathering steel Q345qDNH were investigated. Although the mechanical properties of the two welded joints are lower than those of the base metal, the yield strength, elongation after fracture, impact toughness at 20 °C and À 40 °C of THQ440-NQ-II welded joints are 6.8 %, 23.5 %, 13.7 %, 18 % higher than those of ER50-6 welds, respectively. THQ440-NQ-II welds are ductile fractures and quasicleavage fractures at 20 °C and À 40 °C, respectively; while ER50-6 welds are quasi-cleavage fracture and cleavage fracture at 20 °C and À 40 °C, respectively, the ductile-brittle transition temperature of ER50-6 weld is higher than that of THQ440-NQ-II weld. Comparing the corrosion resistance in 3.5 % sodium chloride (NaCl) solution, THQ440-NQ-II weld is better than the base metal, while ER50-6 welds are lower than the base metal. This is because the nickel, chromium, copper elements contained in the THQ440-NQ-II welding wire can inhibit the formation of Widmanstätten structure and upper bainite during the welding process, refine the structure, increase the content of acicular ferrite, and reduce the ductilebrittle transition temperature of welding joint, improves the corrosion resistance of the weld.