A Study on Improvement of the Analytical Method of Chlorantraniliprole Residue in Herbal Medicine (Rehmannia glutinosa Libosch) using HPLC-UVD

Choi, Jeong Yoon; Lee, Yeong Jae; Ham, Hun-Ju; Ishag, Abd Elaziz Sulieman Ahmed; Hur, Jang-Hyun

doi:10.7585/kjps.2021.25.3.196

kjps

2021

DOI: 10.7585/kjps.2021.25.3.196

|View full text |Cite

A Study on Improvement of the Analytical Method of Chlorantraniliprole Residue in Herbal Medicine (Rehmannia glutinosa Libosch) using HPLC-UVD

Jeong Yoon Choi¹,

Yeong Jae Lee²,

Hun-Ju Ham³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Establishment of Analyzing Method of Fenpropathrin Residue in Angelica dahurica Radix and Osterici Radix

Ham

Leeb²,

Choi

et al. 2023

CTM

View full text Add to dashboard Cite

Background: Angelica dahurica Radix and Osterici radix, are perennial herbs belonging to the family Umbelliferae, which were attacked by red spiders, thus fenpropathrin was registered. Fenpropathrin is important in improving productivity and quality of medicinal herbs due to timely pest control. However, residue may likely remain after harvest, and therefore, the residue analysis is important to ensure pesticides safety management. Objective: This study aimed to establish analysis method for fenpropathrin residues in A. dahurica Radix and O. radix using GLC-ECD and GC-MS/MS. Methods: Samples were moisturized with distilled-water and extracted with acetonitrile. The interferences were removed using SPE cartridges and analyzed by GLC-ECD and GC-MS/MS. Results: Based on pre-experiment results, the analysis method was optimized using double-cleanup method (SPE-GCB/NH2 & SPE silica cartridges). Fenpropathrin peak confirmed by GC-MS at the same retention time and with its mass numbers. Nevertheless, the cleanup processes are laborious and require a rather long time. Thus, additional effortless analysis method was developed using the d-SPE method that can apply to highly selective and sensitive GC-MS/MS. The LOD of GC-ECD and GC-MS/MS was 0.1 and 0.01 ng, respectively. While the LOQ was 0.04 mg/kg for both. Linearity (r2) was > 0.998 (GLC-ECD) and 0.999 (GC-MS/MS). The recoveries at three spiking levels ranged 83.6-103.1% and 89.6-98.0% for A. dahurica Radix and O. radix, respectively. Conclusion: Accuracy of the improved method met the standard of the Korean Ministry of Food and Drug Safety. Therefore, the developed methods expected to be used for analyzing pesticide residues in herbal medicines in Korea and other countries.

show abstract

Establishment of Analyzing Method of Fenpropathrin Residue in Angelica dahurica Radix and Osterici Radix

Ham

Leeb²,

Choi

et al. 2023

CTM

View full text Add to dashboard Cite

show abstract

Optimization of an Analytical Method for Indoxacarb Residues in Fourteen Medicinal Herbs Using GC–μECD, GC–MS/MS and LC–MS/MS

et al. 2022

View full text Add to dashboard Cite

Pesticide residue analysis in medicinal herbs is a challenging task because of the matrix effect and its influence on quantitative analysis despite the continuous development of several new analytical methods and instrumentations. In this study, a modified QuEChERS method was developed for the analysis of indoxacarb residue in medicinal herbs by using the conventional instrument, gas chromatography micro-electron-capture-detector (GC–μECD), and comparing it with gas chromatography–tandem mass spectrometry (GC–MS/MS) and liquid chromatography–tandem mass spectrometry (LC–MS/MS). Samples were extracted with acetonitrile and purified using an NH2 cartridge. The optimized method efficiently removes the co-extractives and offered a limit of quantification of 0.01 mg kg−1. The GC–μECD analysis results of indoxacarb in seven medicinal herbs out of fourteen species at a fortification level of 0.01 mg kg−1 showed a recovery range of 79.7–117.6%, while the rest showed recovery > 120%. Similarly, the recovery of indoxacarb by GC and LC–MS/SM were 74.1–105.9 and 73.0–99.0%, respectively, with a relative standard deviation of <20%. Matrix effects for the majority of medicinal herbs analyzed by GC–MS/MS were >±20%. Whereas the results for LC–MS/MS were <20%, which was within the acceptable range according to the SANTE/11312/2021 guidelines. Considering the performance of the method and alignment with the regulatory guidelines, LC–MS/MS is recommended for the analysis of indoxacarb in selected medicinal herbs.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A Study on Improvement of the Analytical Method of Chlorantraniliprole Residue in Herbal Medicine (Rehmannia glutinosa Libosch) using HPLC-UVD

Cited by 2 publications

References 22 publications

Establishment of Analyzing Method of Fenpropathrin Residue in Angelica dahurica Radix and Osterici Radix

Establishment of Analyzing Method of Fenpropathrin Residue in Angelica dahurica Radix and Osterici Radix

Optimization of an Analytical Method for Indoxacarb Residues in Fourteen Medicinal Herbs Using GC–μECD, GC–MS/MS and LC–MS/MS

Contact Info

Product

Resources

About