A Study on Influence of Donor Hematocrit on the Procedural Parameters of Concentrated Single Donor Platelets Collected by Two Apheresis Devices

Abstract

With improvements in apheresis collection, platelet additive solution (PAS) is steadily replacing plasma as the storage medium in single donor platelets (SDP). Concentrating platelets in SDP with one-third of plasma and two-thirds of PAS is referred as Concentrated-SDP (C-SDP). We studied the influence of donor hematocrit (Hct) in C-SDP procedures. A retrospective study, consisting of 124 and 95 plateletpheresis donors in MCS? and Trima respectively. We compared two apheresis equipments MCS? and Trima with regard to donor hematocrit on procedural parameters such as collection efficiency (CE), collection rate (CR), yield per hour (Y/H), yield per litre (Y/L) and percentage blood volume processed (%BV) during C-SDP procedures. Donors were categorized into two groups with Group A (Hct B 46%) and Group B (Hct [ 46%) based on mean baseline Hct of the study population. Among the 219 procedures, the overall CE was significantly higher for Trima over MCS? equipment (77 vs 56, P \ 0.001). However, there was no difference in procedural outcomes like CE, Y/L, Y/H, CR with MCS? or Trima equipment between groups. %BV processed had a negative correlation with hematocrit in MCS? (r = -0.305, P = 0.001) and no difference was observed with Trima equipment. Donor Hct influences C-SDP collection only in processed blood volume with MCS? equipment. Trima had statistically better performance over MCS? equipments in all procedural parameters during C-SDP procedures. The data will guide apheresis centre to choose equipments based on donor characteristics.

Predicting donor-related factors for high platelet yield donations by classification and regression tree analysis

“…retrospectively observed that donors with a low hematocrit required higher blood volume processing with the MCS+ equipment and not with the Trima/Spectra Optia. 15 However, in the present study, neither the hematocrit nor donor age provided a better split success rate with the CART algorithm between these devices.…”