For more than a decade, researchers and practitioners have been working to advance the implementation of virtual design and construction (VDC) and building information modeling (BIM) in the construction industry. Based on the product-organization-process (POP) research model of VDC/BIM, this paper presents the product-organization-process-infrastructure (POPi) digital framework by adding the core element: the software and hardware infrastructure. This paper discusses the element models and corresponding relationship of the POPi framework in terms of practical characteristics: the diversity of BIM applications and software in high-rise megaprojects and cross-organizational task interdependence. In addition, by combining the practices of the Suzhou Zhongnan Center, this study analyzes the four core element models of the POPi framework and discusses the typical applications and benefits to projects in design and the early stage of construction based on the element models. The research results provide a theoretical framework for the BIM application and related software development of similar projects.