A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley

Murtaza, Imtiyaz; Mushtaq, Dhuha; Margoob, Mushtaq Ahmad; Dutt, Amit; Wani, Nisar Ahmad; Ahmad, Ishfaq; Bhat, Mohan Lal

doi:10.3748/wjg.v12.i25.4033

Cited by 44 publications

(41 citation statements)

References 16 publications

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“…The Kashmir Valley is located in the northern part of India, walled by the mighty Himalayas, its unique ethnic population live in discrete temperate environmental conditions and have distinctive eating habits, which play an overwhelming role in the development of GIT cancers over the genetic factors (Murtaza et al, 2006;Salam et al, 2009;Sameer et al, 2010a,b). As previously reported (Siddiqi et al, 1992), the etiology and incidence of various GIT cancers in this population have been attributed to the probable exposure to nitroso compounds, amines and nitrates reported to be present in the local foodstuffs.…”

Section: Discussionmentioning

confidence: 99%

“…Colorectal cancer is the third most common cancer in men and the second most common cancer in women worldwide (Jemal et al, 2011). To date, Kashmir has been reported as a high-incidence area of gastrointestinal (GIT) cancers (Mir et al, 2005;Murtaza et al, 2006). In Kashmir Valley, CRC represents the third most common GIT cancer after esophageal and gastric (Sameer et al, 2010a,b).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we carried out a case-control study in our population to determine if this MTHFR C677T polymorphism is associated with an altered risk of developing CRC, as many dietary habits (Siddiqi et al, 1992;Mir et al, 2005;Murtaza et al, 2006;Sameer et al, 2010b) of our population have already been established as risk factors for the development of GIT cancers. We also investigated whether there is a link between these risk factors and the MTHFR C677T genotype and CRC predisposition.…”

Section: Introductionmentioning

confidence: 99%

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Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population

Sameer¹,

Shah²,

Nissar³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been implicated as a risk factor for the development of various cancers. We investigated MTHFR C677T genotype frequency in colorectal cancer cases in the Kashmiri population and correlated this information with the known clinicopathological characters of colorectal cancer, in a case-control study. Eighty-six colorectal cancer cases were studied for MTHFR C677T polymorphism, compared to 160 controls taken from the general population, employing the PCR-RFLP technique. We found the frequency of the three different genotypes of MTHFR in our ethnic Kashmir population, i.e., CC, CT and TT, to be MTHFR C677T polymorphism and colorectal cancer 68.6, 20.9 and 10.4% among colorectal cancer cases and 75.6, 16.9 and 7.5% among the general control population, respectively. There was a significant association between the MTHFR TT genotype and colorectal cancer in the higher age group. We conclude that the MTHFR C677T polymorphism slightly increases the risk for colorectal cancer development in our ethnic Kashmir population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population

Sameer¹,

Shah²,

Nissar³

et al. 2011

Genet. Mol. Res.

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“…After metastasis has occurred, patient 5-year survival after surgery unfortunately falls dramatically from 90% to less than 10% (O'Connell et al, 2004). Kashmir has often being reported as a high-incidence area for gastrointestinal cancers (Murtaza et al, 2006). It has been found to be the fourth most common cancer in males, holds a third rank amongst the female population of Kashmir and has been observed to constitute 8.3% of all GIT cancers.…”

Section: Introductionmentioning

confidence: 99%

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Rasool

Kadla²,

Khan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir

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“…Poor nutrition, tobacco smoking, betel quid chewing, alcohol consumption are major known risk factors [14]. The dietary risk factors, specifi cally identifi ed in North-East India are hot salty soda tea, red chillies and high-nitrate diet especially locally grown Brassica leaves [15]. Hot salty soda tea induces chronic irritation of the oesophageal epithelium and predisposes carcinogenic substance to initiate tissue-specifi c malignant transformation.…”

Section: Epidemiologymentioning

confidence: 99%

Management of oesophageal cancer

Tong

Law

2009

Indian J Surg

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Oesophageal cancer is a disease of dismal prognosis. There are variations of epidemiology among different ethnic groups and geographic regions. India is a country with high incidence. This can be attributed to the interplay between environmental, dietary factors and life-style of the population of the country. Optimal therapeutic strategy for patients with oesophageal cancer demands individual consideration.

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A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley

Cited by 44 publications

References 16 publications

Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population

Risk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Management of oesophageal cancer

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