A Study on Peripheral Neuropathy and Its Related Risk Factors Associated With hba1c Levels

Abstract

Diabetic peripheral neuropathy (DPN) patients frequently feel persistent pain, which is described as painful diabetic peripheral neuropathy (PDPN), which begins in both feet and frequently spreads to the calves, fingers, and hands. PDPN not only causes pain, but also affects patients' sleep, emotions, mental state, and everyday activities, resulting in a low quality of life and a significant financial burden. The goal of this study was to monitor if there was a link between the prevalence, pattern, and related risk factors of diabetic peripheral neuropathy and hemoglobin A1C (HbA1c) levels. In this crosssectional study, 150 type-2 diabetic patients were screened for DPN with PDPN and their HbA1c level was measured in every three months. DPN, PDPN and non-painful DPN were confirmed in patients displaying both clinical manifestations of neuropathy and neurological abnormalities assessment. DPN was detected in 24% (n = 36), while PDPN was found at 15% (n = 23) of the total patients. The prevalence of PDPN is 63.88% (n = 23) and non-painful DPN is 36.11% (n = 13) of total DPN (n = 36). Out of total PDPN (n = 23), the prevalence of symmetrical pain is 65% (n = 15), asymmetrical 35% (n = 8), sensory 26% (n = 6), motor 13% (n = 3), mixed (sensorimotor) 61% (n = 14), lower limb involvement 48% (n = 11), upper limb13% (n = 3) and both limb 39% (n = 9). In comparison to patients without DPN, both PDPN and non-painful DPN, patients had greater HbA1c levels (p<0.05). Furthermore, advanced age and longer diabetes duration were considerable and significant (p<0.05) risk factors for DPN with PDPN and non-painful DPN respectively. Overall, the findings imply that elevated HbA1c levels are closely linked to DPN, PDPN and non-painful DPN in type-2 diabetic patients and that HbA1c might be used as a predictive marker for DPN with PDPN and non-painful DPN in the patients studied. J. Bio-Sci. 29(2): 123-138, 2021 (December)

Prevalence and correlates of vibration perception threshold based diabetic peripheral neuropathy in Gujarati urban population: A cross sectional study

“…As in line with literature, gender,[ 18 ] hyperlipidemia[ 15 ] were not significant predictors of VPT. Similarly, in accordance with other researchers, duration of diabetes,[ 7 8 13 14 15 ] presence of DPN symptoms,[ 5 ] and family history for diabetes were significant predictors for VPT. However, age and glycemic control were not predictors as against other studies.…”

“…Glycemic control is the benchmark of disease control and complications for type 2 diabetics. [ 5 7 8 13 14 15 ] We found all three means of glycemic triad—FPG, 2hPG, and HbA1c to correlate with VPT and poor glycemia to impose significant risk for DPN. HbA1c is highlighted as a biomarker of diabetic foot peripheral neuropathy[ 3 ] and gold standard for diabetic control.…”

“…[ 12 ] So, it is better to insinuate VPT screening early and optimally. Such high occurrence of DPN in our study population can be attributed to high mean age,[ 7 13 14 ] high mean duration (9 years),[ 7 8 13 14 15 ] ethnic risk,[ 7 ] lack of physical activity,[ 5 ] poor glycemic control (in less than half only),[ 5 7 8 13 14 15 ] poor health literacy, nonspecificity of neuropathy symptoms,[ 7 ] and personal negligence.…”

Serum C-Reactive Protein to Albumin Ratio as a Reliable Marker of Diabetic Neuropathy in Type 2 Diabetes Mellitus

“…Variability in glycated hemoglobin levels was suggested to be correlated with the presence of diabetic neuropathy in diabetic population [44]. Similarly, studies in different populations were linked diabetic neuropathy to the increased levels of HbA1c [45]. In addition, extensive control of glucose by reducing HbA1c to target levels in a short interval result in amelioration of neuropathy in diabetic subjects [46].…”