Slab center segregation occurs due to fluid flow in the continuous casting process, and is caused by shell bulging, thermal shrinkage, and so on. Their influences on center segregation evolution have been investigated separately in the past, whereas the combined effect is rarely reported. In this work, both shell bulging and thermal shrinkage on center segregation formation are studied. Accordingly, the control strategy of mechanical reduction to improve center segregation is analyzed. The results show that solid phase moves outward and inward periodically with shell bulging, which promotes the transport of rejected solute to the slab center. Near solidification end, solid phase still moves outward with thermal shrinkage, and the concentrated liquid is pushed out and flows to center part. Therefore, the transport behaviors with shell bulging and thermal shrinkage are completely different, and center segregation will be worse when both are considered. As solid phase is compressed by mechanical reduction, enriched liquid transported downward is suppressed and center segregation is reduced. With a greater reduction amount allocated in the later stage, center segregation can be obviously improved. Furthermore, the control strategy of mechanical reduction is to alleviate the relative movement between liquid and solid near the solidification end.