A study on safety and efficacy of intralesional vitamin D3 in cutaneous warts

Potlapati, Amruthavalli; Gangaiah, Narendra; George, Neethu Mary

doi:10.18203/issn.2455-4529.intjresdermatol20203749

Cited by 4 publications

(6 citation statements)

References 7 publications

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“…There are very few studies on the treatment of difficult-to-heal palmoplantar warts with Bleomycin. [ 15 16 17 18 19 20 ] Table 3 compares the outcome of our study to those of others in the treatment of difficult-to-heal palmoplantar warts with IL Bleomycin. Complete clearance was reported in 95.5% of patients, which was similar to Shumer et al ’s finding of 94% after only two sessions of treatment, others reported 73–92%, which could be due to a lower number of sessions or a longer time between sessions.…”

Section: Discussionmentioning

confidence: 97%

“…Swelling at the injection site lasting more than a week was seen in 8.2%, compared to 86% in the study by Aziz et al . [ 20 ] No systemic toxicity or Raynaud’s phenomenon was observed during study and follow-up period. [ 16 ] Recurrence was not seen in our study but recurrence was high in Aziz et al which may be because of a smaller number of sessions.…”

Section: Discussionmentioning

confidence: 99%

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Intralesional vitamin D3 versus Bleomycin for difficult-to-heal palmoplantar warts: A comparative study

Prathibha

Varghese

Aithal

2023

JCAS

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Introduction: Difficult-to-heal or recalcitrant palmoplantar warts are notoriously resistant to treatment, making treatment difficult and challenging. To improve the outcome and overcome the difficulties, various treatment options have been tried, but none is gold standard. Many comparative studies have been undertaken to assess the efficacy of various drugs; however, none of them are standardized, and no single treatment is effective. Various comparative efficacy studies have been conducted but, to the best of our knowledge, no study has been conducted comparing intralesional (IL) injection (inj) vitamin D3 (Vit D3) with the chemotherapy drug IL inj Bleomycin for difficult-to-heal palmoplantar warts. We conducted a trial to evaluate the efficacy of IL inj Vit D3 versus IL inj Bleomycin in the treatment of difficult-to-heal palmoplantar warts. The purpose of this study was to compare the efficacy of IL inj vitamin D3 versus IL inj Bleomycin as biological response modifier therapy in difficult-to-heal palmoplantar warts. Materials and Methods: A cohort of 48 patients with difficult-to-heal warts were consecutively assigned to one of two groups: Group 1 IL inj Vit D3 (0.2–0.5 mL inj vitamin D3 600,000 IU solution 15 mg/mL) or Group 2 IL inj Bleomycin (0.2–0.4 mL of 1 U/mL solution) for a maximum of four treatments spaced 2 weeks apart, with a maximum of five warts treated at each visit for both groups. Warts were measured at baseline and at each subsequent visit. Wart’s resolution was measured as 1–25%, 2–50%, 3–75%, and 4–100% reduction. Patients were followed-up for 3 months after treatment. Results: All the 48 patients completed the study, with 26 receiving IL inj Vit D3 with complete resolution in 88.5%, partial resolution in 11.5%, and side effects in 6.2%. In 22 patients receiving IL inj Bleomycin, 95.5% had complete resolution, 4.5% had partial resolution, and 8.2% had side effects. Maximum resolution was observed in the third session. We found no recurrence after 3 months. Conclusion: IL inj Vit D3 and IL inj Bleomycin are both safe and effective in treating difficult-to-heal palmoplantar warts with better outcomes and patient satisfaction. IL Bleomycin was significantly more effective than IL Vit D3, although the difference was not statistically significant.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Intralesional vitamin D3 versus Bleomycin for difficult-to-heal palmoplantar warts: A comparative study

Prathibha

Varghese

Aithal

2023

JCAS

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“…11 Close to our study, a therapeutic response of Intralesional injections of vitamin D3 with complete resolution was found by Akula et al 12 Potlapati et al found complete resolution of plantar warts in (76.6%), no response in 3.4% of cases. 13 Intralesional vitamin D3 is an effective treatment modality in treating plantar warts. Differences in complete clearance rates are attributed to host immunity and strain of HPV.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Intralesional Vitamin D3 in the Treatment of Plantar Warts

Javed

Tahir

Hanif

et al. 2022

PAFMJ

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Objective: To explore the effectiveness and safety of intralesional cholecalciferol (vitamin D3) for the treatment of plantar warts. Study Design: Prospective longitudinal study. Place and Duration of Study: Tertiary Care Hospital, Multan Pakistan, from Sep 2019 to Aug 2020. Methodology: Sixty-two patients with warts of varying sizes and duration were included in the study. Intralesional lignocaine was used to anaesthetize the skin. About 0.2ml injection of cholecalciferol (vitamin D3) solution (600,000 IU, 15mg/mL) was injected with a 30-gauge needle to the base of the wart under aseptic measures. A maximum of 4 warts were injected per session at 3-week intervals until resolution or for amaximum of 6 treatments. Patients were followed up for six months after the last injection for recurrence. Results: Sixty-two patients completed the study, including 45(72.58%), patients who had complete clearance of warts following injection 14(22.5%) which showed partial response and 3(4%) cases had no response. Conclusions: Intralesional vitamin D3 is a safe and effective treatment for plantar warts.

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“…Common warts are the commonest type of benign epidermal proliferation of the skin caused by human papillomavirus, transmitted mainly by direct skin-to-skin contact [1,2] . Despite warts usually, having self-limiting and spontaneous resolution taking place within months to years, there are chances of spreading to other sites and other persons; so local destruction using, electrocoagulation, cryotherapy, laser therapy, or topical keratolytic is a commonly employed treatment modality performed [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Potassium Hydroxide 10% for the Treatment of Common Warts

Makki

Saddik²,

Abdel-Aleem³

2022

International Journal of Medical Arts

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Article informationBackground and Aim: Common wart is considered one of the common diseases that are caused by the human papillomavirus; despite the high tendency for spontaneous recovery, it needs treatment. Topical application of keratolytic agent on virus-infected cells is one of the standards in the treatment, potassium hydroxide [KOH] is a strong, less irritating keratolytic agent, less painful, and can be safely used in all age groups. This study is aimed to evaluate topical 10% KOH in the treatment of common warts as regards safety and efficacy. Patients and methods:This open therapeutic trial study was performed on 70 patients with a total of 168 common warts, who were treated with topical 10% KOH solution once at night for twelve weeks. The patients were evaluated at the end of the study to record the percentage of improvement and adverse effects and follow up for 3 months to detect any recurrence for those patients who showed complete cure. Results:At the end of the study about 70 % of patients showed complete recovery of their warts. Moreover, we didn't observe any serious adverse effects, however, Hyperpigmentation was presented in 31.4% of patients, with no significant difference as regard location of warts. Conclusion:Topical KOH 10 % solutions are promising, effective, safe, and well-tolerated treatments for common warts.

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A study on safety and efficacy of intralesional vitamin D3 in cutaneous warts

Cited by 4 publications

References 7 publications

Intralesional vitamin D3 versus Bleomycin for difficult-to-heal palmoplantar warts: A comparative study

Intralesional vitamin D3 versus Bleomycin for difficult-to-heal palmoplantar warts: A comparative study

Efficacy and Safety of Intralesional Vitamin D3 in the Treatment of Plantar Warts

Clinical Efficacy of Potassium Hydroxide 10% for the Treatment of Common Warts

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