2014
DOI: 10.1017/s1751731114000433
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A study on some welfare-related parameters of hDAF transgenic pigs when compared with their conventional close relatives

Abstract: Pigs are increasingly used in medical research as transgenic laboratory animals; however, little knowledge is presently available concerning their welfare assessment. The aim of the present study was to investigate some welfare-related parameters of transgenic pigs intended for xenotrasplantation (human decay-accelerating factor (hDAF)) when compared with their conventional (i.e. not transgenic) close relatives (full sibs and half sibs). A total of 14 Large White female transgenic pigs and 10 female non-transg… Show more

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Cited by 16 publications
(14 citation statements)
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“…A direct and positive relationship between faecal glucocorticoid metabolites, blood cortisol, and adrenal activity was demonstrated by Morrow et al (2002). A minimally invasive method to assess stress levels over time through cortisol determination in bristles of growing pigs and sows has been recently proposed by Martelli et al (2014) and by Bacci et al (2014). It would be interesting to test the feasibility and reliability of this technique in ruminant species as well.…”
Section: Importance and Assessment Of Animal Welfarementioning
confidence: 99%
“…A direct and positive relationship between faecal glucocorticoid metabolites, blood cortisol, and adrenal activity was demonstrated by Morrow et al (2002). A minimally invasive method to assess stress levels over time through cortisol determination in bristles of growing pigs and sows has been recently proposed by Martelli et al (2014) and by Bacci et al (2014). It would be interesting to test the feasibility and reliability of this technique in ruminant species as well.…”
Section: Importance and Assessment Of Animal Welfarementioning
confidence: 99%
“…Piglets were videotaped over the 24 hours once or twice a week, for a total of 6 videotaping sessions in trial 1, and 12 videotaping session in trial 2. Videos were examined by a single trained observer and the behavioural patterns were assessed by scan sampling technique at 10-min intervals according to predetermined ethogram for heavy pigs (Martelli et al 2014) reporting the following behaviours: standing inactive, sitting inactive (dog-sitting), sternal recumbency, lateral recumbency, walking, eating, drinking, exploring the floor, social interactions. The ethogram was adapted to the specificities in piglets' behaviour and to the trial by adding the following behaviours: tail biting, interaction with the environmental enrichment, interaction with other cage structures, belly nosing.…”
Section: Behavioural Traitsmentioning
confidence: 99%
“…Pigs were videotaped once every month, corresponding to 4 videotaping sessions for each replication. Videos were examined by a single trained operator and the behavioral pattern was assessed by scan sampling technique at 10-min intervals according to predetermined ethogram for heavy pigs (Martelli et al, 2014) reporting the following behaviors: standing inactive, sitting inactive (dog sitting), sternal recumbency, lateral recumbency, walking, eating, drinking, chain/bar biting, exploring the floor, and social interactions. The choice of videotaping pigs only during the second phase was based on the assumption that behavioral alterations are more likely to occur during this period, when less space per animal is available and feed restriction becomes more severe (Scipioni et al, 2009).…”
Section: Behavioral Traitsmentioning
confidence: 99%