A study on the action of vitamin E supplementation on plasminogen activator inhibitor type 1 and platelet nitric oxide production in type 2 diabetic patients

Vignini, Arianna; Nanetti, Laura; Moroni, Cinzia; Testa, Roberto; Sirolla, C.; Marra, Maurizio; Manfrini, S.; Fumelli, Daniele; Marcheselli, Fiorella; Mazzanti, Laura; Rabini, R. A.

doi:10.1016/j.numecd.2007.01.002

Cited by 13 publications

(13 citation statements)

References 40 publications

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“…Recent reports have shown that response to vitamin E supplementation in diabetics may be modulated by variants of HaptoglobulinA (34,41,42) and plasminogenA-1 (43,44) genes. These reports support the idea that genetic factors modulate responses to supplemental E. We have observed that the effect of vitamin E supplementation on TNFa production was dependent on TNFa -308G .…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms at Cytokine Genes May Determine the Effect of Vitamin E on Cytokine Production in the Elderly , ,

Belisle¹,

Leka²,

Delgado-Lista³

et al. 2009

The Journal of Nutrition

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Vitamin E has been shown to affect cytokine production. However, individual response to vitamin E supplementation varies. Previous studies indicate that cytokine production is heritable and common single nucleotide polymorphisms (SNP) may explain differences in cytokine production between individuals. We hypothesize that the differential response to the immunomodulatory actions of vitamin E reflects genetic differences among individuals, including SNP at cytokine genes that modulate cytokine production. We used data from a double-blind, placebo-controlled 1-y vitamin E (182 mg d,l-alpha-tocopherol) intervention study in elderly men and women (mean age 83 y) to test this hypothesis (vitamin E, n = 47; placebo, n = 63). We found that the effect of vitamin E on tumor necrosis factor (TNF)-alpha production in whole blood stimulated for 24 h with lipopolysaccharide (1.0 mg/L) is dependent on TNFalpha -308G > A. Participants with the A/A and A/G genotypes at TNFalpha -308G > A who were treated with vitamin E had lower TNFalpha production than those with the A allele treated with placebo. These observations suggest that individual immune responses to vitamin E supplementation are in part mediated by genetic factors. Because the A allele at TNFalpha has been previously associated with higher TNFalpha levels in whole blood and isolated immune cells, our observations suggest that the antiinflammatory effect of vitamin E is specific to those genetically predisposed to higher inflammation. Further studies are needed to determine the biological mechanism driving the interaction between vitamin E treatment and TNFalpha -308G > A and its implications for disease resistance.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms at Cytokine Genes May Determine the Effect of Vitamin E on Cytokine Production in the Elderly , ,

Belisle¹,

Leka²,

Delgado-Lista³

et al. 2009

The Journal of Nutrition

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“…As shown in Table 4, among the 7 trials [122][123][124][125][126][127][128] in patients at risk of cardiovascular disease, 5 were performed in patients with diabetes mellitus. In these 5 trials, [122][123][124][125][126] the daily amount of vitamin E ranged from 100 to 600 IU, and follow-up lasted from 2 to 10 weeks.…”

Section: Vitaminsmentioning

confidence: 99%

“…In these 5 trials, [122][123][124][125][126] the daily amount of vitamin E ranged from 100 to 600 IU, and follow-up lasted from 2 to 10 weeks. An antiplatelet effect was observed in all but 1 study; however, that study included patients who were also taking aspirin.…”

Section: Vitaminsmentioning

confidence: 99%

Nutrition, Supplements, and Vitamins in Platelet Function and Bleeding

2010

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“…From our recent observations [62] a beneficial effect exerted by vitamin E supplementation in T2D patients can be hypothesized.…”

Section: Resultsmentioning

confidence: 99%

“…/K ? -ATPase activity in T2D subjects [62]. Vitamin E is able to counteract endothelial impairment in T2D patients and might therefore be effective in preventing early endothelial damage, possibly representing a new tool for endothelial protection.…”

Section: Vitamin E and Diabetesmentioning

confidence: 92%

Vitamin E, diabetes and related diseases: an update

Vignini

Alidori

Montesi

et al. 2010

Mediterr J Nutr Metab

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Natural vitamin E is a mixture of tocopherols and tocotrienols synthesized only by plants. It is very difficult to determine the optimal dietary intake of vitamin E, but there is a general agreement indicating a level of 8 mg/ day (12-15 IU). This value seems to be sufficient only to prevent deficiency syndromes of vitamin E. In humans, vitamin E is absorbed together with nutritional lipids in the proximal part of the intestine and released in the lymph within chylomicrons. Vitamin E supplementation, as other minerals and vitamins, is able to participate in the decrease of oxidative stress in diabetic patients by improving glycemic control and/or by other mechanisms related to its antioxidant activity, therefore cooperating to the control of diabetic complications. Many interventional trials evaluating the effect of antioxidant supplementation on insulin resistance, plasma glucose levels and risk of T2D give inconsistent results. At present, a controversial hypothesis about the role played by vitamin E supplementation still exists. In fact, while laboratory data report great cellular and biochemical beneficial actions, clinical trials have failed to support these claims. Concerning clinical trials, the discrepancies have been attributed to differences in selection of individuals, dosage, chemical forms of vitamin E, duration of treatment, stage of the disease and geographical area. Because of these variables, further studies aimed to clarify the relationship between diabetes, cardiovascular risk factors and vitamin E are necessary.

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A study on the action of vitamin E supplementation on plasminogen activator inhibitor type 1 and platelet nitric oxide production in type 2 diabetic patients

Cited by 13 publications

References 40 publications

Polymorphisms at Cytokine Genes May Determine the Effect of Vitamin E on Cytokine Production in the Elderly , ,

Polymorphisms at Cytokine Genes May Determine the Effect of Vitamin E on Cytokine Production in the Elderly , ,

Nutrition, Supplements, and Vitamins in Platelet Function and Bleeding

Vitamin E, diabetes and related diseases: an update

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