23We evaluated the association of blood pressure with blood levels of cadmium, lead, and cadmium
26This cross-sectional study enrolled adolescents aged at 10-18 years-old who completed a health 27 examination survey and had blood measurements of lead and cadmium. The association of adjusted 28 mean differences in diastolic and systolic blood pressure with doubling of blood lead and cadmium 29 were estimated by regression of blood pressure against log2-transformed blood metals and their 30 quartiles after covariate adjustment. Adjusted odds ratios for prehypertension were calculated for 31 log2-transformed blood levels of lead and cadmium and their quartiles. Our analysis of adolescents 32 in Korea indicated that blood levels of lead and cadmium were not significantly associated with 33 increased blood pressure or risk of pre-hypertension. However, the cadmium+lead level was 34 associated with pre-hypertension. Previous studies showed that blood levels of lead and cadmium
35were associated with increased blood pressure and risk of hypertension in adult populations. We 36 found no such effect in Korean adolescents, although the cadmium+lead level was associated with 37 prehypertension. These differences may be because adolescents generally have lower levels of 38 these blood metals or because adolescents only rarely have hypertension.