24 Na is a beta and gamma emitting radioisotope that is widely used in medical field as medical radiotracing. This radioisotope with a half-life of 14.977 hours is mostly produced in cyclotrons. The cross-section of a radioisotope is used to obtain various data about the production of that radioisotope. In cases where it is not possible to obtain experimental data, missing data can be completed with cross-section calculations and the obtained data can be compared with experimental, saving time, cost and effort. This study was carried out for detailed analysis of cross-section calculations for 24 Na isotope, which has a wide range of usage in medicine. In this direction, the cross-sections obtained from different computation programs were compared with literature data of the reactions. Production cross-sections of the 24 Na isotope were investigated in the 23 Na(d,p) 24 Na, 24 Mg(n,p) 24 Na, 25 Mg(n,n+p) 24 Na, 25 Mg(p,2p) 24 Na, 26 Mg(d,α) 24 Na and 27 Al(n,α) 24 Na reactions with the equilibrium and pre-equilibrium models of nuclear reaction codes of TALYS 1.95 and EMPIRE 3.2. Results were compared with experimental data from the EXFOR data library. The relevance of the models to the reactions was discussed and calculations were made using the relative variance analysis method to determine the most consistent model.