A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985

Auld, Niccole; Flood, Krystal A.; Kesharwani, Tanay; Cavnar, Peter J.

doi:10.1080/10426507.2022.2085272

Cited by 1 publication

(1 citation statement)

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“…Some studies indicate their ability to inhibit the growth and spread of cancer cells in the laboratory. In particular, the research group of N. Auld et al (4) explored the ability of compounds with a thiophene fragment to exhibit cytotoxicity in myeloid leukaemia, noting a number of positive results. It may indicate the possibility of using these compounds in the fight against particular types of cancer.…”

Section: Introductionmentioning

confidence: 99%

Oxidation reactions of cyclopent-2-en-1-yl thiophene derivatives

Klimko,

Pisanenko,

Koshchii

et al. 2023

Innovaciencia

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Introduction: Thiophene derivatives are common in a large number of natural compounds. In addition, their biological activity provides great opportunities for synthetic organic chemistry. In particular, cyclopentenylthiophenes have high antimicrobial activity, can affect various inflammatory mechanisms, and can be effective in the treatment of cancer. However, in research, it is essential to first learn how to obtain compounds in pure form and to select such synthesis conditions that, when scaled up and introduced into widespread production, the affordability and safety of the processes would meet the needs of both consumers and pharmaceutical companies. Material and Methods: As an oxidant, meta-chloroperoxybenzoic acid was used, which allowed exploring its oxidative properties and advantages of use in more detail. Results and Discussion: In the course of this work, several cyclopentenylthiophene derivatives were synthesised, the ratio of isomers in the synthesis of these compounds was analysed, and the advantages and disadvantages of the synthesis methods were discussed. On the other hand, there are several issues that require additional research, including the effect of temperature conditions, electrophilicity of substituents and other factors on the course of the epoxidation reaction for cyclopentenylthiophenes. Conclusion: The research of thiophene derivatives is relevant both from the standpoint of exploring electronic effects when substituents with different acceptor properties are introduced into the heterocyclic aromatic system and from the standpoint of medicinal chemistry, as they are interesting biologically active objects with high chemical stability, good penetration of cell membranes, ability to affect enzyme activity, bind to receptors.

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Section: Introductionmentioning

confidence: 99%