1984
DOI: 10.1007/bf00799166
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A study on the doubleMannich reaction with 1,3-diphenylacetone

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1984
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Cited by 14 publications
(9 citation statements)
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“…That the acetonyl fragment of the acetoacetyl group is involved in the formation of the y-piperidone or bispidinone ring systems in the course of a double Mannich reaction, is in line with many reported cases which have been reviewed by Blicke [7] and Tramontini [8], and with our recent studies on double Mannich reaction [9,10]. Claisen condensation of 1 with diethyl oxalate in presence of sodium methoxide led to the formation of ethyl(2-oxaloacetyl)-l,3-indandione (6).…”
Section: Introductionsupporting
confidence: 75%
“…That the acetonyl fragment of the acetoacetyl group is involved in the formation of the y-piperidone or bispidinone ring systems in the course of a double Mannich reaction, is in line with many reported cases which have been reviewed by Blicke [7] and Tramontini [8], and with our recent studies on double Mannich reaction [9,10]. Claisen condensation of 1 with diethyl oxalate in presence of sodium methoxide led to the formation of ethyl(2-oxaloacetyl)-l,3-indandione (6).…”
Section: Introductionsupporting
confidence: 75%
“…The hybridization of two different bioactive Mannich bases has been reported in a limited number of cases . However, there is no report on the synthesis of hybrid Mannich bases related to isoindolin‐1,3‐dione ( 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…Compounds 8b , 12 , and 18a are of limited solubility in common 1 H NMR solvents. Compounds 3 , 15a – d , 17c , and 25 were prepared as previously described.…”
Section: Methodsmentioning
confidence: 99%