A Study on the Effect of Antenatal Corticosteroids on Glycemic Response in Preterm Patients

Fernandes, Shannon F; D\'Cunha, Rithesh J; D\'Almeida, Joylene

doi:10.5005/jp-journals-10006-2016

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Similarly, PPBS was elevated in 54.65% cases on day 2 of antenatal corticosteroids and reduced to 26.7% and 13.95% on day 4 and day 5 respectively. 16 In our study FBS and RBS levels were raised at 24hrs and then gradually declined to baseline. Similar results were also shown by other studies.…”

Section: Effect Of Antenatal Corticosteroids On Maternal Blood Glucos...supporting

confidence: 45%

Effect of Antenatal Corticosteroids on Maternal Blood Glucose Levels

2023

JPMI

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Objective: To study the effect of antenatal corticosteroids on maternal blood glucose levels.Methodology: This observational study was conducted in the Department of Obstetrics and Gynecology at Hayatabad Medical Complex, Peshawar, after obtaining ethical approval from the Institutional Ethical Review Board. All patients admitted to the labor suite for antenatal corticosteroids were included in the study, while patients with diabetes or any other medical disorder requiring corticosteroids were excluded. Patients were selected using a non-probability convenient sampling technique. They were given two doses of Betamethasone (12mg) intramuscularly, with a 24-hour interval between doses. Maternal blood sugar levels were checked before administering the first dose of Betamethasone. Subsequently, patients were placed on a sugar profile for five days. All the data were entered in a pre-designed proforma.Result: A total of 247 patients were included in the study. The majority of the patients were multigravida (50.20%) and belonged to the age group of 21-30 (50.20%). The mean age of the patients was 26.4 ± 2.3 years. The majority of the patients (72.46%) had deranged blood sugar levels, either falling within the range of impaired glucose levels or full-blown diabetes. Antenatal corticosteroids mainly affected fasting blood sugar (FBS) and post-prandial blood sugar levels. Conclusion:Antenatal corticosteroids administered to normoglycemic patients result in significant but transient hyperglycemia. However, in the majority of patients, blood sugar levels normalize within five days following the administration of corticosteroid doses.

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Section: Effect Of Antenatal Corticosteroids On Maternal Blood Glucos...supporting

confidence: 45%

Effect of Antenatal Corticosteroids on Maternal Blood Glucose Levels

2023

JPMI

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“…Following steroid therapy, the increase in WBC count is 3300 cells/cumm, and this should not be mistaken for infection. 22,23…”

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confidence: 99%

Study of Maternal Blood Glucose Levels and Blood Count after Betamethasone Therapy in Preterm Pregnancy

Gopalakrishna,

Azmathulla,

Fernandes

et al. 2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Background: Premature birth is one of the largest problems in obstetrics today and the most significant cause of neonatal morbidity and mortality. An important complication of preterm birth is respiratory distress syndrome. Corticosteroids to the mother will help in accelerating the fetal lungs maturity. This study was undertaken to evaluate the blood sugar changes and white cell count in the mother, respectively, following antenatal corticosteroids.Objectives of the study: To evaluate changes in blood glucose levels, total leukocyte count, and differential count following betamethasone therapy in preterm labor. Materials and methods: A prospective cohort study was performed in women at 28-34 weeks of gestation with preterm labor receiving betamethasone. Fasting and postprandial blood sugar glucose values were obtained on days 2, 4, and 6 after betamethasone therapy from the day of admission. Total count (TC) and differential count (DC) were also measured on day 2 and day 4 from the day of admission. Results: In this study, FBS started rising from day 2 of betamethasone, with 93% having increased blood sugar. There was a significant change in FBS levels (p < 0.001) and PPBS levels (<0.001) following antenatal steroid therapy. Corticosteroid induced a significant neutrophilia and lymphocytopenia on day 2 following administration. Conclusion: Betamethasone resulted in an acute rise in fasting blood sugar and postprandial blood sugar, and leukocytosis is expected to peak in 24 hours, and the magnitude is small.

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A Study on the Effect of Antenatal Corticosteroids on Glycemic Response in Preterm Patients

Cited by 2 publications

References 13 publications

Effect of Antenatal Corticosteroids on Maternal Blood Glucose Levels

Effect of Antenatal Corticosteroids on Maternal Blood Glucose Levels

Study of Maternal Blood Glucose Levels and Blood Count after Betamethasone Therapy in Preterm Pregnancy

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