Given a 3-uniform hypergraph H having a set V of vertices, and a set of hyperedges $$T\subset \mathcal {P}(V)$$
T
⊂
P
(
V
)
, whose elements have cardinality three each, a null labelling is an assignment of $$\pm 1$$
±
1
to the hyperedges such that each vertex belongs to the same number of hyperedges labelled $$+1$$
+
1
and $$-1$$
-
1
. A sufficient condition for the existence of a null labelling of H (proved in Di Marco et al. Lect Notes Comput Sci 12757:282–294, 2021) is a Hamiltonian cycle in its 2-intersection graph. The notion of 2-intersection graph generalizes that of intersection graph of an (hyper)graph and extends its effectiveness. The present study first shows that this sufficient condition for the existence of a null labelling in H can not be weakened by requiring only the connectedness of the 2-intersection graph. Then some interesting properties related to their clique configurations are proved. Finally, the main result is proved, the NP-completeness of this characterization and, as a consequence, of the construction of the related 3-hypergraphs.