This qualitative systematic study analyzes the entrepreneur concept and its transformation during the COVID-19 pandemic. The study reports the results of a metasearch of keywords such as entrepreneurial traits, entrepreneur’s characteristics, business adaptations due to COVID-19, COVID-19 protocols, management responses to COVID-19, and entrepreneurship during COVID-19, among others. It has fulfilled the objective of confirming the presence of an adaptation and transformation process of the skill set and traits of a successful entrepreneur Trans-COVID-19 vis-a-vis Pre-COVID-19. Prevalent characteristics during the COVID-19 pandemic include adaptability, technological knowledge, creativity, innovation, ability to network, and creating new relationships. These characteristics suggest avenues for further investigation. Research opportunity lies in examining potential shifts in strategic orientations that may arise from the post-traumatic effects on organizations due to the profound changes brought about by the COVID-19 pandemic. Furthermore, the recognition of these new traits and shifts in managerial paradigms during the Trans-COVID-19 period raises significant questions about potential changes in academic processes aimed at developing future entrepreneurs.