Purpose: This study investigated the effect of job stress on job satisfaction and quality of life of beauty-related workers.Methods: Data were collected from beautyrelated workers, and 358 surveys were analyzed using the SPSS WIN 21.0 program. Analysis methods included factor analysis, descriptive statistics, correlation analysis, linear regression analysis, and mediation regression analysis.Results: First, respondents were generally female, unmarried, 20–29 years old, had college or graduate school education, were hairdressers, and had a monthly average income of less than 2 million won. Second, the analysis of descriptive statistics and correlations between job stress, job satisfaction, and quality of life showed a statistically significant negative correlation with job satisfaction and quality of life for each sub-factor of job stress. Job satisfaction was found to have a statistically significant positive (+) correlation with quality of life. Third, job satisfaction partially mediated the relationship between job stress and quality of life as well as the relationship between role-related stress, home-related stress, and quality of life. The relationship between interpersonal stress, reward-related stress, and quality of life of job stress is full mediation.Conclusion: The efficient management of beauty-related workers’ job stress improves their job satisfaction and quality of life. Therefore, for managing each job’s stress factor, creating a manual appropriate to that type of beauty-related workplace will be helpful.