A Study on the Level of T3, T4, TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves’ Hyperthyroidism among South Indian Population

Veeramuthumari, P.; Isabel, W.; Kannan, Kurunthachalam

doi:10.1007/s12291-010-0093-z

Cited by 16 publications

(12 citation statements)

References 24 publications

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“…In accordance with our results, studies conducted among different populations showed an association of CTLA-4 gene 49 A/G polymorphism with Graves' disease including Caucasians (Yanagawa et al, 1995), Japanese (Yanagawa et al, 1997), Koreans (Park et al, 2000), Chinese children (Chong et al, 2008) and Taiwanese (Weng et al, 2005) and in South Indian population (Veeramuthumari et al, 2011). However, the study of Frydecka et al (2004), showed that the distribution of CTLA-4 exon 1 A (49)G genotype, allele and phenotypic frequencies did not differ between patients with GD and healthy subjects in Polish population.…”

Section: Discussionsupporting

confidence: 92%

“…The lowest ''G'' allele Science Publications AJBB frequency (48%) was noted in Caucasian GD population and among healthy individuals in Iranian (37%) (Kalantari et al, 2003) and Caucasian population (38%) (Bednarczuk et al, 2003). The study of Veeramuthumari et al (2011), shows that the ''G'' allele frequency is 63% among South Indian population, which is comparable to that of the Taiwanese ''G'' allele frequency (67%) (Weng et al, 2005) and Koreans (68%) (Park et al, 2000).…”

Section: Discussionmentioning

confidence: 95%

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Ctla-4 Gene Polymorphism in Relation to Thyroid Disorders in Patients With Chronic Hepatitis C Under Interferon Alpha Therapy

El-Khair

Metwali

El-Maksoud

et al. 2012

American Journal of Biochemistry and Biotechnology

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Thyroid autoimmunity and dysfunction have reported as side effects of interferon-α treatment. The CT60 and exon 1+49 A/G polymorphisms in the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene have linked to susceptibility to autoimmune disease. The aim of this research was to analyze the frequencies of CTLA-4 CT60 and +49 A/G polymorphisms and evaluate both polymorphisms as indicators of thyroid disorder susceptibility in chronic HCV Egyptian patients under interferon therapy. This study was carried out on 114 chronic HCV patients under combined therapy of interferon-α and Ribavirin. From them, 60 chronic HCV patients without thyroid disorder were considered the control group. The other 54 patients were having thyroid disorder either hypothyroidism (N = 35) or Grave's Disease (GD) (N = 19). For all subjects, the genotypes of CTLA-4 gene CT60 and +49 A/G polymorphisms were studied using RFLP technique. For +49 A/G polymorphism, the genotypes frequencies in controls were: AA (30), AG (31.7) and GG (38.3%). Whereas, in hypothyroidism patients, the AA, AG and GG genotypes frequencies were (20), (57.1%) and (22.9%) respectively, while in grave's disease, the AA, AG and GG genotypes frequencies were (26.3 (57.9) and (15.8%) respectively. The AG genotype was significantly associated with thyroid disease. As regards CT60 polymorphism, the genotypes frequencies in controls were: CC (38.3), CT (35) and TT (26.7%). Whereas, in hypothyroidism patients, the CC, CT and TT genotypes frequencies were (60), (20) and (20%) respectively, while in grave's disease, the CC, CT and TT genotypes frequencies were (68.4), (15.8) and (15.8%) respectively. The CC genotype was significantly associated with thyroid disorders. CTLA-4 gene +49A/G and CT60 polymorphisms confer susceptibility to autoimmune thyroid disorder and confirm usefulness of CTLA-4 genotyping in predicting thyroid disorder in chronic HCV patients under interferon therapy.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Ctla-4 Gene Polymorphism in Relation to Thyroid Disorders in Patients With Chronic Hepatitis C Under Interferon Alpha Therapy

El-Khair

Metwali

El-Maksoud

et al. 2012

American Journal of Biochemistry and Biotechnology

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“…Methodology to be followed for the discovery of single nucleotide polymorphism in polycystic kidney disease Genomic DNA preparation: [68,69].…”

Section: Trends In Potential Therapies and Clinical Trialsmentioning

confidence: 99%

“…Electrophoretic analysis of genomic DNA: the isolated DNA was confirmed by 0.7% agarose gel electrophoresis [68,69].…”

Section: Trends In Potential Therapies and Clinical Trialsmentioning

confidence: 99%

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Discovery of Single Nucleotide Polymorphism in Polycystic Kidney Disease among South Indian (Madurai) Population

Veeramuthumari¹,

Isabel²

2018

Chronic Kidney Disease - From Pathophysiology to Clinical Improvements

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The kidneys serve an essential regulatory role in most of the animals, including vertebrates and some invertebrates. They are important in the urinary system and also serve homeostatic functions like regulation of electrolytes, maintenance of acid-base balance and regulation of blood pressure (via maintaining salt and water balance). They also serve as natural filter of the blood and remove wastes that are diverted to the urinary bladder. By producing urine, the kidneys excrete wastes such as urea and ammonia. The kidneys are responsible for reabsorption of water, glucose, amino acids and trace elements. They also produce hormones including calcitriol, renin and erythropoietin. The kidney is approximately 11-14 cm long, 6 cm wide and 4 cm thick. Each adult kidney weighs between 125 and 170 g in males and between 115 and 155 g in females. The left kidney is typically slightly larger than the right kidney. Each kidney is made up of about 1 million microprocessor units called nephrons.

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Simultaneous quantification of thyroid hormones using an ultrasensitive single-molecule fourplex nanoimmunosensor in an evanescent field

Lee

et al. 2023

Biosensors and Bioelectronics

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A Study on the Level of T3, T4, TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves’ Hyperthyroidism among South Indian Population

Cited by 16 publications

References 24 publications

Ctla-4 Gene Polymorphism in Relation to Thyroid Disorders in Patients With Chronic Hepatitis C Under Interferon Alpha Therapy

Ctla-4 Gene Polymorphism in Relation to Thyroid Disorders in Patients With Chronic Hepatitis C Under Interferon Alpha Therapy

Discovery of Single Nucleotide Polymorphism in Polycystic Kidney Disease among South Indian (Madurai) Population

Simultaneous quantification of thyroid hormones using an ultrasensitive single-molecule fourplex nanoimmunosensor in an evanescent field

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