The annual global building demolition is burdensome due to the rapid development of cities. The pollution associated with building demolition severely endangers the urban environment. Soundless chemical demolition agents (SCDAs) can effectively avoid environmental hazards in the demolition of concrete buildings. However, related literature on optimal hole layout design is still vacant. The demolition of reinforced concrete slabs was therefore explored in this paper. In total, 18 slab specimens were tested. Results showed that the slab specimens were demolished into several blocks due to sufficient development of cracks. Following this, a set of complete evaluation system was proposed. First, the volumetric expansion ratio of SCDAs was provided as a new evaluation index. Based on this evaluation index, the influences of critical parameters and the influence mechanism of reinforcements were investigated. Second, a novel multi‐parameter hole layout computational model was established. With this model, an optimal hole layout scheme could be obtained. Finally, the application prospect of SCDAs was discussed. This work can open up a new vision for the demolition industry.