In order to meet the needs of the simulation function of prefabricated building construction layout, the author proposes a technology based on the Markov model. The main content of this technology is based on Markov model technology and takes Jinzhong Zhaimen as an example to conduct spatial scale research, according to the sensitivity of spatial scale, and finally through analysis, a systematic research method is constructed. Experimental results show that in the cell size range used, 80 m and 400 m can be regarded as the cell size threshold and limit value affecting the simulation accuracy, and when the cell size is below 80 m, the simulation result coefficient values are all more accurate. Conclusion. A technical study demonstrates that the Markov model can meet the needs of prefabricated building construction layout simulation functions.