A study on the polymorphisms of the renin–angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria

Abstract

Introduction: Several studies have assessed the relationship between blood pressure (BP) and polymorphisms within the genes encoding angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R) and angiotensin-converting enzyme (ACE). However, considering the relatively large discrepancy in frequency and impact of these variants between ethnic groups and populations, still unavailable data from Algerian population are needed. Objective: Our purpose is to evaluate the association between the AGT M235T, AT1R +1166A/C and ACE I/D polymorphisms and variations in systolic (SBP), diastolic (DBP) and pulse pressure (PP) values. Methods: The associations with BP were assessed in a representative sample of 115 male subjects free of coronary heart disease (CHD). The AGT M235T, AT1R +1166A/C and ACE I/D polymorphisms were determined by PCR-ASO and PCR-RFLP analysis, respectively. Results: We showed no associations between the AGT M235T, AT1R +1166A/C nor the ACE I/D polymorphisms with variations in BP values. However, concerning the ACE I/D polymorphism, subjects carrying the ACE I allele tended to have higher SBP (+4.1 mmHg) and PP values (+3.2 mmHg) than DD subjects (adjusted p = 0.087 and p = 0.102, respectively). Conclusion:The ACE I/D polymorphism needs further investigation in a larger Algerian study, especially concerning its putative impact on SBP and PP.

Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study

“…Regarding association studies of ACE I/D polymorphism with hypertension, only two studies were conducted on Egyptians and they associated the D allele with hypertension [ 11 ], mainly on noise exposure [ 12 ]. In Arabs, no correlation with hypertension was found in Emirates [ 29 ], in Lebanon [ 30 ] nor in Algeria [ 31 ]. When an association was found, hypertension was accompanied by other factors such as age in Lebanese [ 32 ], obesity in Tunisians [ 13 ] and Emiratis [ 14 ] or diabetes and obesity in Saudi patients [ 8 ].…”

Modulation of cardiometabolic risk and CardioRenal syndrome by oral vitamin D 3 supplementation in Black and White Southern Sahara residents with chronic kidney disease Stage 3: focus on racial and ethnic disparities

“…In this context, our data can be supported by the activation of RAAS mediators which has been proposed to argue this racial disparity in black population observed in the incidence of hypertension and cardio-renal complications, including Ang II and aldosterone [ 92 ]. Indeed, the hypersecretion of aldosterone as a potential risk factor for cardiovascular events in the CKD population, in particular, the higher rate of hypertension-related in Algerian SS blacks [ 93 ]. The authors seem to attribute this disorder to increase on dietary salt.…”

Recherche d’association entre les polymorphismes du gène codant l’Ornithine Transcarbamylase (OTC) et l’Infarctus du Myocarde dans la population Ouest-Algérienne

“…Les premiers résultats de cette étude ont permis d'une part de déterminer le profil du bilan lipidique et lipoprotéinique de la population oranaise [3], et d'autre part de caractériser des polymorphismes des gènes candidats impliqués dans le métabolisme des lipides [4]. Nous nous sommes également intéressés à évaluer l'impact des polymorphismes de gènes candidats impliqués dans le métabolisme de la L-arginine sur le risque de la survenue de l'infarctus du myocarde et les valeurs de pressions artérielles, tels que les gènes codant la Nosynthase endothéliale (eNOS) [5], l'arginase 1 (ARG1) [6], l'angiotensinogène et l'enzyme de la conversion de l'angiotensine [7].…”