A Study on the Prognostic Evaluation of Carbon Ion Radiotherapy for Head and Neck Adenocarcinoma with C-11 Methionine PET

Abstract

The determination of treatment effectiveness using TNR in CIRT for head and neck adenocarcinoma is an independent factor for predicting local recurrence, the incidence of metastasis, and the prognosis. MET-PET is therefore considered to be useful for determining the treatment effectiveness in patients with head and neck adenocarcinoma undergoing CIRT.

Synthesis of 68Ga-labeled DOTA-nitroimidazole derivatives and their feasibilities as hypoxia imaging PET tracers

“…20 The radionuclides most commonly used for PET are 18 F and 11 C, which are produced using an accelerator. [21][22][23] Other metallic positron emitters, such as, 86 Y, 64 Cu, and 68 Ga also can be used for PET, [24][25][26][27][28][29][30] and of these, 68 Ga is the most promising, because it can be obtained using a commercially available generator system consisting of an inorganic matrix immobilizing the parent radionuclide 68 Ge. 31 This availability has led to great interest in the development of 68 Ga-labeled agents, because of its cost and convenience benefits.…”

Non-18F-FDG PET/CT in the management of patients affected by HNC

“…Metastases were observed more frequently in the group with lower rates of change. Therefore, [ 11 C]MET PET can be considered useful for determining the treatment effectiveness in patients with head and neck adenocarcinoma undergoing CIRT [60].…”

Synthesis of Endogenous Compounds Labeled with11C for Positron Emission Tomography

“…All methods provided 11 C methionine according to the pharmaceutical regulation and established imaging with 11 C methionine as a gold standard for visualization of glicomas in neurooncology [3,12,13] and supplementary in adenocarcinoma [14] or in radiation therapy planning [15]. 11 C acetate is an important endogenous substrate in the Krebs cycle and takes part in metabolism of fatty acids and cholesterols.…”