A Study on the Relationship between Reflux Esophagitis and Periodontitis

Abstract

Objective Metabolic syndrome and dental erosion have been demonstrated to correlate with gastroesophageal acid reflux disease (GERD), while periodontitis has been reported to have a positive relationship with metabolic syndrome. However, no correlation between periodontitis and GERD has yet been reported. We therefore investigated the relationship between periodontitis and GERD. Methods The subjects consisted of 280 individuals who visited the Health Center for a detailed medical checkup examination. Each underwent upper endoscopy and periodontitis examinations, with the latter performed by measuring the concentrations of lactate dehydrogenase and hemoglobin in saliva. The subjects were divided into those with positive and negative periodontitis findings, and the prevalence rates of endoscopically proven reflux esophagitis, dyslipidemia, hypertension, and hyperglycemia were compared. Results The number of subjects positive for periodontitis was 93, while 187 had negative findings. The prevalence of reflux esophagitis was not different between the positive and negative groups (8.6% vs. 8.0%). In addition, a multiple logistic regression analysis did not identify a positive relationship between the presence of periodontitis and reflux esophagitis. On the other hand, dyslipidemia and hypertension were more frequently observed in the subjects that were positive for periodontitis. Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia.

Systemic medical conditions and periodontal status in older individuals

“…Similarly, no effect on the severity of periodontal status, especially when compared to the standard of oral hygiene, was reported by Krohn . Studies have also evaluated the effect of gastroesophageal acid reflux on periodontal disease but are limited and inconclusive . In the present investigation, self‐reported acid reflux/GERD was significantly negatively associated with moderate bone loss ( p = 0.004) when compared to none to mild bone loss.…”

Prevalence of reflux esophagitis in obese Japanese undergoing bariatric surgery

“…In general, the prevalence of RE was 6.1–13.7% in Japan . The present study shows that the prevalence of RE in severely obese Japanese patients was significantly higher than the average prevalence of RE in Japan.…”

Influence of Helicobacter pylori infection on periodontitis

“…The concentrations of LDH and Hb in collected saliva samples were determined using automatic chemical analyzers (LDH: Labospect 008, Hitachi High‐Technologies, Tokyo; Hb: Diana OC‐sensor, Eiken Chemical Co. LTD, Tokyo), according to the manufacturers' instructions. A concentration of LDH ≥ 350 U/L and/or Hb ≥ 2 μg/mL was defined as positive for periodontitis, based on the criteria of the Shimane Dental Association shown in previous studies …”