Objectives: The aim of the present study was to examine the levels of complete blood count (CBC) parameters (Neutrophil, lymphocyte, platelets, MPV, NLR, and PLR) in patients with both perforated eardrums and dysfunctional eustachian tubes to determine which of these parameters might be reliable biomarkers of chronic otitis media prior to surgery, as inflammation is significant component of middle ear pathology.
Materials and methods: In this study, we enrolled 95 patients with 18-65 years old. Patients with chronic otitis media (perforated tympanic membranes) more than three months in duration who have no draining ears, were enrolled in Okmeydani Training & Research Hospital. Patients were divided into three groups: Group 1 is “Open eustachian tube” group in which pressure changes (if evident) during swallowing were recorded on stepladder-type graphs; Group 2 is “Blocked” group, who could not neutralize the negative pressure even by repeated swallowing. Group 3 is “Partially blocked” group in whom some residual pressure persisted even after five swallows. The groups were compared in terms of laboratory tests.
Results: There was a statistically significant difference between 3 groups in terms of platelet levels (p>0.05). We found that group 2 / blocked eustachian tube had significantly increased platelet counts values when compared to the group 1 and 3. There was no significant difference among group 1 and group 3. There was no statistically significant difference between the 3 groups in terms of neutrophil, lymphocyte count, MPV, NLR, PLR levels, bone and air hearing thresholds.
Conclusion: We found that the platelet count increased in chronic otitis media patients with blocked eustachian tube. This may be a simple and inexpensive biomarker with acustic impedencemeter tests supporting eustachian dysfunction before tympanoplasties.
Key Words: Hematological biomarkers; eustachian tube dysfunction; chronic otitis media