A study on the response of PLGA 85/15 under compression and heat-treatment testing cycles

Castro, Paulo Bastos deÂ; Salmoria, Gean Vitor; Roesler, Carlos Rodrigo de Mello; Rosa, Edison da; Fancello, Eduardo Alberto

doi:10.1007/s11043-020-09451-3

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…As can be seen in Figure 4a, both stiffness and strength of yarns reduce their values proportionally to the period of bath immersion, behavior that was already expected and clearly indicates mechanical degradation. 1,3,7 Nevertheless, due to the nonlinearities involved—both material and geometrical—the understanding of how much the hydrolytic degradation changes the stiffness over time is not straightforward in the present case.…”

Section: Discussionmentioning

confidence: 95%

“…Over the last years, researches related to biodegradable/bioabsorbable polymers have increased considerably, ranging from studies concerning synthesis, processing and manufacturing to works focused on the mechanical characterization and constitutive modeling of these materials. [1][2][3][4][5][6][7] Particularly in biomedical applications, absorbable polymers are broadly are proposed to model the tested material. Moreover, a nonlinear curve fitting procedure based on Particle Swarm Optimization (PSO) was used to identify the constitutive parameters in view of the experimental data.…”

Section: Introductionmentioning

confidence: 99%

“…Over the last years, researches related to biodegradable/bioabsorbable polymers have increased considerably, ranging from studies concerning synthesis, processing and manufacturing to works focused on the mechanical characterization and constitutive modeling of these materials. 1-7 Particularly in biomedical applications, absorbable polymers are broadly applied, covering from simple sutures yarns to complex orthopedic and vascular implants, such as screws, suture anchors, maxillofacial plates, vascular stents, among others. 4,8-16 Concerning previously mentioned applications, the motivation that leads to the usage of bioabsorbable implants are manifold: to avoid complications resulting from a further surgical intervention to remove the implant; to reduce the so-called stress-shielding , i.e.…”

Section: Introductionmentioning

confidence: 99%

“…: sutures, scaffolds, basis to drug delivery systems and implants in general. 4,7,20,21 In this regard, the experimental procedure is based on mechanical tensile tests performed after the yarns were subjected to predetermined periods within a temperature controlled bath in the absence of mechanical loads. This bath corresponds to a phosphate-buffered saline solution aiming to emulate the intracorporeal environment.…”

Section: Introductionmentioning

confidence: 99%

“…Based on a sound variational constitutive approach within a finite element framework, de Castro et al 3 developed a thermodynamically consistent coupled ductile-hydrolytic damage model for numerical simulations of bioabsorbable polymer implants. More recently, de Castro et al 7 approached experimentally and numerically the non-homogeneous compression behavior of poly(lactic-co-glycolic) acid (PLGA). In such a study, the large strain mechanics of the material, the strain rate sensitivity and the effect of a heat-treatment procedure were investigated.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical characterization of hydrolysis effects on the stiffness of bioabsorbable polymeric filaments: An experimental and modeling approach based on a simple constitutive damage model

Carniel

Castro

Santos

et al. 2021

Polymers and Polymer Composites

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This manuscript presents an experimental and modeling approach in order to characterize the stiffness loss of bioabsorbable polymer filaments due to hydrolysis. In this regard, bioabsorbable suture yarns (poly(lactic-co-glycolic) acid—PLGA) were chosen as a representative material for the present investigation. The observed mechanical response was characterized by means of a thermodynamically consistent constitutive variational framework. Usually, two different damage variables are assumed to take place in this class of materials: a hydrolytic damage (long-term degradation) and a strain-driven damage (short-term degradation). This work concerns the proposition of a constitutive model that only considers the hydrolytic damage, in which a specific strain energy and a proper dissipation damage potential were tailored to model the tested material. A nonlinear curve fitting procedure based on Particle Swarm Optimization was performed to identify the constitutive parameters. A set of numerical simulations demonstrates the effectiveness of the proposed constitutive model to predict damage-induced creep and damage-induced stress relaxation, behaviors that can be used as design criteria in absorbable implants. The main achieved results show that the proposed constitutive approach leads to a simple but effective model capable to drive the first steps in the design of absorbable biomedical devices. The present variational framework can be extended to study the constitutive response of other bioabsorbable polymers, accounting for viscous and/or plastic behaviors.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

“…Over the last years, researches related to biodegradable/bioabsorbable polymers have increased considerably, ranging from studies concerning synthesis, processing and manufacturing to works focused on the mechanical characterization and constitutive modeling of these materials. 1-7 Particularly in biomedical applications, absorbable polymers are broadly applied, covering from simple sutures yarns to complex orthopedic and vascular implants, such as screws, suture anchors, maxillofacial plates, vascular stents, among others. 4,8-16 Concerning previously mentioned applications, the motivation that leads to the usage of bioabsorbable implants are manifold: to avoid complications resulting from a further surgical intervention to remove the implant; to reduce the so-called stress-shielding , i.e.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mechanical characterization of hydrolysis effects on the stiffness of bioabsorbable polymeric filaments: An experimental and modeling approach based on a simple constitutive damage model

Carniel

Castro

Santos

et al. 2021

Polymers and Polymer Composites

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Effect of Thermo-mechanical Post-treatments on Injection-Molded PLGA 85:15 Maxillofacial Plates

Neto

Deon

Roesler

et al. 2022

Biomedical Materials & Devices

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Fibrous Structures: An Overview of Their Responsiveness to External Stimuli towards Intended Application

Ferreira,

Gonçalves,

Antunes

et al. 2024

Polymers

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In recent decades, the interest in responsive fibrous structures has surged, propelling them into diverse applications: from wearable textiles that adapt to their surroundings, to filtration membranes dynamically altering selectivity, these structures showcase remarkable versatility. Various stimuli, including temperature, light, pH, electricity, and chemical compounds, can serve as triggers to unleash physical or chemical changes in response. Processing methodologies such as weaving or knitting using responsive yarns, electrospinning, as well as coating procedures, enable the integration of responsive materials into fibrous structures. They can respond to these stimuli, and comprise shape memory materials, temperature-responsive polymers, chromic materials, phase change materials, photothermal materials, among others. The resulting effects can manifest in a variety of ways, from pore adjustments and altered permeability to shape changing, color changing, and thermal regulation. This review aims to explore the realm of fibrous structures, delving into their responsiveness to external stimuli, with a focus on temperature, light, and pH.

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A study on the response of PLGA 85/15 under compression and heat-treatment testing cycles

Cited by 3 publications

References 17 publications

Mechanical characterization of hydrolysis effects on the stiffness of bioabsorbable polymeric filaments: An experimental and modeling approach based on a simple constitutive damage model

Mechanical characterization of hydrolysis effects on the stiffness of bioabsorbable polymeric filaments: An experimental and modeling approach based on a simple constitutive damage model

Effect of Thermo-mechanical Post-treatments on Injection-Molded PLGA 85:15 Maxillofacial Plates

Fibrous Structures: An Overview of Their Responsiveness to External Stimuli towards Intended Application

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