A study on the severity and relevance of porcine circovirus type 2 infections in Dutch fattening pigs with respiratory diseases

Wellenberg, G.J.; Bouwkamp, F. T.; Wolf, P.J. van der; Swart, W.A.J.M.; Mombarg, MJ; Gee, A.L.W. de

doi:10.1016/j.vetmic.2009.10.003

Cited by 29 publications

(25 citation statements)

References 13 publications

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“…The presence of pleuritis, irrespective of severity of those lesions, has previously been associated with a reduction in weight gain (Hartley et al, 1988;Jäger et al, 2010;Wellenberg et al, 2010). In our study, pigs with pleuritis were on average 1.24 kg lighter than those without lesions at the individual level.…”

Section: Discussionsupporting

confidence: 61%

“…Economic losses associated with pleuritis can be attributed to slow growth and reduced feed conversion (Wellenberg et al, 2010). Infections with M. hyopneumoniae result in significant losses to the pig industry through reduced weight gain, decreased feed efficiency and increased days to slaughter (Thacker and Minion, 2012) the most serious effects of which are seen in the finishing stages (Straw et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

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Associations between EP-like lesions and pleuritis and post trimming carcass weights of finishing pigs in England

et al. 2017

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Associations between EP-like lesions and pleuritis and post trimming carcass weights of finishing pigs in England

et al. 2017

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“…Pasteurella multocida is an agent of major importance within the PRDC, and several Brazilian studies (Borowski 2001, Morés 2006, Borowski et al 2007, Kich et al 2007, Heres 2009 and international studies (Kim et al 2003, Ono et al 2003, Cappuccio et al 2004, Pijoan 2006, Hansen et al 2010, Wellenberg et al 2010, Pors et al 2011, 2016 have reported its role. In this study, the involvement of P. multocida with severe respiratory disease in finishing pigs was evaluated, confirming the co-infection of this agent with Influenza type A virus and M. hyopneumoniae but not with PCV2.…”

Section: Discussionmentioning

confidence: 99%

“…Historically, P. multocida is considered to be a secondary infection, aggravating pulmonary infections caused by M. hyopneumoniae and PCV2 (Kim et al 2003, Pijoan 2006, Hansen et al 2010, Wellenberg et al 2010, Fablet et al 2011, Pors et al 2011. However, researchers in southern Brazil (Borowski 2001, Morés 2006, Borowski et al 2007, Kich et al 2007 and Argentina (Cappuccio et al 2004) have suggested that P. multocida is a primary agent capable of causing severe respiratory disease, nevertheless its pathogenesis and invasiveness mechanisms are not clearly described yet.…”

Section: Introductionmentioning

confidence: 99%

Anatomopathological pneumonic aspects associated with highly pathogenic Pasteurella multocida in finishing pigs

et al. 2017

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The bacterium Pasteurella multocida is a frequent cause of porcine respiratory disease complex in finishing pigs. Historically, the bacterium is recognized as an opportunistic agent, causing secondary bacterial pneumonia in pigs. Several Brazilian reports have suggested the ability of P. multocida to cause primary pulmonary infection that leads to the death of finishing pigs prior to slaughter. The aim of this study was to evaluate anatomopathological pulmonary findings associated with P. multocida infection that were obtained from animals with clinical respiratory disease and from animals at slaughter. Twenty-five lung samples from 14 herds of finishing pigs with acute clinical respiratory disease and 19 lungs collected at slaughter from a different set of 14 herds were studied. In all lung samples, bacterial isolation was performed, and only samples with pure P. multocida growth were included in the study. Gross and histopathological lesions were evaluated, as well as Influenza A, porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae co-infections. Pleuritis and pericarditis were more often observed in clinical samples (P<0.05). Moreover, there was a numerical trend indicating that pericarditis, lymphadenomegaly and cavity exudates were more often present in clinical samples. Thirteen lung samples were negative to M. hyopneumoniae, Influenza A and PCV2 by immunohistochemistry (IHC), with only P. multocida identified. In these cases, gross lesions such as pleuritis, pericarditis and lymphadenomegaly were always present, and no histologic lesions indicative of other agents such as Actinobacillus pleuropneumoniae, Actinobacillus suis or Haemophilus parasuis were observed. These findings suggest the ability of some P. multocida isolates to cause primary respiratory and systemic infection. However, in this study, it was not possible to determine specific virulence markers to explain these findings.

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“…Alban and others (2013) have previously reported a similar observation in Denmark, where the increased use of vaccines against respiratory diseases (including PCV-2-related infections) corresponded to a decline in the use of antimicrobials for the treatment of respiratory infections in all age groups. PCV-2-triggered immunosuppression has frequently been reported to enable secondary bacterial infections to develop (Segalés and others 2004, Kixmöller and others 2008, Wellenberg and others 2010). This effect may substantially increase the need for antimicrobials among PCV-2-infected pigs (Jensen and others 2010, Vigre and others 2010).…”

Section: Discussionmentioning

confidence: 99%

Influence of porcine circovirus type 2 vaccination on the level of antimicrobial consumption on 65 Austrian pig farms

et al. 2016

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The administration of antibiotics to farm animals is an important contemporary topic. Veterinarians, pig producers, politicians, retailers and consumers all have a vested interest in reducing antimicrobial use on farm, while ensuring adequate health and welfare of food-producing animals. Vaccination programmes may be used to reduce the overall level of clinical disease in a population, subsequently leading to a decline in antimicrobial use. In 2008, a vaccination programme against porcine circovirus type 2 (PCV-2) was initiated in Austria. In the retrospective observational study presented here, farm medication records (2008-2011) from 65 conventional pig farms were evaluated. As PCV-2 has been shown to lead to generalised immunosuppression, enabling secondary bacterial infections to occur, the authors hypothesised that PCV-2 vaccination would decrease antimicrobial consumption at farm level. Firstly, we focused on the annual antimicrobial consumption expressed as the number of administered animal daily doses per kg liveweight (nADDkg/kg/year). Secondly, a linear mixed effects model was applied to evaluate the influence of PCV-2 vaccination on the antimicrobial consumption at farm level. The interaction between farm type and PCV-2 vaccination was found to be a highly significant factor (P=0.0002) influencing antimicrobial use at farm level. The estimated impact of PCV-2 vaccination revealed a highly significant (P<0.001) decline in total antimicrobial drug use from 1.72 ADDkg/kg/year to 0.56 ADDkg/kg/year on finishing farms, whereas only a negligible decline was detectable on farrow-to-finish farms.

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A study on the severity and relevance of porcine circovirus type 2 infections in Dutch fattening pigs with respiratory diseases

Abstract: 18This study was set up to get more insights in the severity and relevance of porcine circovirus type 2 (PCV2) infections in 27(pneumonia) at slaughter, and the 8 "low" herds had low percentages of pneumonia at slaughter.

Cited by 29 publications

References 13 publications

Associations between EP-like lesions and pleuritis and post trimming carcass weights of finishing pigs in England

Associations between EP-like lesions and pleuritis and post trimming carcass weights of finishing pigs in England

Anatomopathological pneumonic aspects associated with highly pathogenic Pasteurella multocida in finishing pigs

Influence of porcine circovirus type 2 vaccination on the level of antimicrobial consumption on 65 Austrian pig farms

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