A study on the value of computer-assisted assessment for SPECT/CT-scans in sentinel lymph node diagnostics of penile cancer as well as clinical reliability and morbidity of this procedure

Abstract

BackgroundBecause of the increasing importance of computer-assisted post processing of image data in modern medical diagnostic we studied the value of an algorithm for assessment of single photon emission computed tomography/computed tomography (SPECT/CT)-data, which has been used for the first time for lymph node staging in penile cancer with non-palpable inguinal lymph nodes. In the guidelines of the relevant international expert societies, sentinel lymph node-biopsy (SLNB) is recommended as a diagnostic method of choice. The aim of this study is to evaluate the value of the afore-mentioned algorithm and in the clinical context the reliability and the associated morbidity of this procedure.MethodsBetween 2008 and 2015, 25 patients with invasive penile cancer and inconspicuous inguinal lymph node status underwent SLNB after application of the radiotracer Tc-99m labelled nanocolloid. We recorded in a prospective approach the reliability and the complication rate of the procedure. In addition, we evaluated the results of an algorithm for SPECT/CT-data assessment of these patients.ResultsSLNB was carried out in 44 groins of 25 patients. In three patients, inguinal lymph node metastases were detected via SLNB. In one patient, bilateral lymph node recurrence of the groins occurred after negative SLNB. There was a false-negative rate of 4 % in relation to the number of patients (1/25), resp. 4.5 % in relation to the number of groins (2/44). Morbidity was 4 % in relation to the number of patients (1/25), resp. 2.3 % in relation to the number of groins (1/44). The results of computer-assisted assessment of SPECT/CT data for sentinel lymph node (SLN)-diagnostics demonstrated high sensitivity of 88.8 % and specificity of 86.7 %.ConclusionsSLNB is a very reliable method, associated with low morbidity. Computer-assisted assessment of SPECT/CT data of the SLN-diagnostics shows high sensitivity and specificity. While it cannot replace the assessment by medical experts, it can still provide substantial supplement and assistance.

Study on the Application Value of CT Thin-Layer Scan Data Assisted 3D Printing Technology in Hip and Knee Replacement

“…Hip and knee replacement is a procedure to solve moderate-to-severe knee osteoarthritis and has a high success rate. It mainly relaxes the soft tissue and bone tissue of the knee joint through the balance of the joint space, corrects the mechanical axis of the lower limbs, rebuilds the joint stability, relieves the symptoms of the patient, reduces the time in bed, achieves normal early activities, and restores the knee limbs [ 1 ]. Biomechanical analysis shows that correct alignment of prosthetic components is one of the most critical features of successful hip and knee replacement, and the key is accurate intraoperative amputation.…”

Detection of lymph node metastases in penile cancer

“…SNL was not detected in the zones inferior to the saphenofemoral junction nor was there drainage directly into the pelvis ( 18 ). Another study of this combined technology showed SPECT/CT to have a high sensitivity and specificity of 88.8% and 86.7%, respectively ( 36 ).…”