Diarrheal disease is the second leading cause of under-five mortality, about two billion cases of diarrheal disease are registered annually worldwide, and 1.9 million children under the age of five die each year from diarrhea.A descriptive study was conducted to assessing the self-efficacy among mother′s for preventing diarrhea in children under 5 years and find out the association between self-efficacy of mother′s for preventing diarrhea with her selected demographic variables. The study started from the period of 19 th September 2020 to 15 th March the 2021.Convenience sample of 200 mothers of children under five years was selected. The data were described statistically and analyzed through the use of descriptive and inferential statistical analysis procedures.Results revealed that mothers self-efficacy evaluated moderate level in the prevention of diarrhea in their children represented (64.3%), with respect to the relation of there is non significant differentiation at P>0.05 among mother's responding regarding studied domains and their (SDCv.) except between occupation variable level of education variable and socio-economic status since significant relationships are accounted at P<0.01.The study concludes there is non significant differentiation among mother's responding regarding studied domains and child (SDCv.) except between method of breastfeeding in the first six months, at any age the mother began to give her child extra food has the child previously suffered diarrhea since significant relationships and recommended that community based diarrhea prevention programs" need to adopt the mothers self-efficacy scale to assess mothers 'perceived risks in order to implement specific interventions that will boost and sustain Diarrhea prevention strategies at the health household levels.