A Study to Assess the Levels of Salivary Ferritin in Iron Deficiency Anemia Subjects and Healthy Subjects

B, Lokesh Sundaram; Rathnavelu, Vidhya; Sathiavelu, Mythili; Ganesh, Akila; Anandan, Soumya

doi:10.7759/cureus.17241

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…In particular, it was discovered that serum-iron-deficient participants could have salivary iron even higher than that of the controls . Moreover, an increase in blood iron levels owing to the action of the enzyme lactoferrin follows a drop in saliva iron as a result of physical, mental, or emotional stress. , Thus, the significant decrease in salivary iron in healthy volunteers could be associated with the mobilization of iron stores to boost their blood levels and refill their resources depleted by the load, which results in the successful restoration of the participant’s psychological well-being.…”

Section: Discussionmentioning

confidence: 99%

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

Portnova,

Khayrullina,

Mikheev

et al. 2024

ACS Chem. Neurosci.

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The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. In this study, we tested the dynamics of behavioral parameters, resting-state electroencephalogram (EEG), and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 individuals with OCD before and after an emotional antisaccade task. The eye-movement data served as a measure of behavioral performance. Our research revealed consistently higher manganese concentrations in the OCD group compared to healthy volunteers associated with a higher EEG ratio of amplitude transformation and symptom severity. The dynamics of salivary microelements and resting-state EEG, possibly influenced by cognitive and emotional load during the anticsaccade task, differed between groups. In healthy volunteers, there was a decrease in salivary iron level with an increase in high-frequency power spectral density of EEG. The OCD group showed a decrease in salivary copper with an increased Hjorth mobility of EEG.

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Section: Discussionmentioning

confidence: 99%

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

Portnova,

Khayrullina,

Mikheev

et al. 2024

ACS Chem. Neurosci.

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Effect of the Emotional Antisaccade Tasks on Salivary Trace Elements and Resting State EEG in Patients with Obsessive-Compulsive Disorder

Portnova,

Khayrullina,

Mikheev

et al. 2023

Preprint

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The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time, especially in terms of emotional or cognitive effort. In this study, we tested the dynamics of behavioral parameters, electroencephalogram (EEG) parameters, and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 OCD patients using an emotional antisaccade task with an overlap design. We recorded both 64-channel EEG and eye-movement data and investigated the task-solving effectiveness and linear and non-linear features of the EEG resting states before and following the experimental paradigm. Our research revealed consistently increased manganese concentrations in OCD patients compared to healthy volunteers associated with higher amplitude variability of the EEG and symptom severity. The dynamics of salivary microelements and resting state EEG associated with task solving differed between groups. In healthy volunteers, there was a decrease in salivary iron with an increase in high-frequency PSD. In patients with OCD, there was a decrease in salivary copper with increased Hjorth mobility of the EEG.

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Response to Treatment with Melatonin and Clonazepam versus Placebo in Patients with Burning Mouth Syndrome

Castillo-Felipe

Tvarijonaviciute

López-Arjona

et al. 2022

JCM

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Objective: to evaluate the efficacy of melatonin and clonazepam versus placebo in patients with burning mouth syndrome (BMS). Methods: a prospective double-blind study was carried out in patients with BMS and randomized to three groups: melatonin (1 mg once a day), clonazepam (0.5 mg/twice a day), or a placebo once a day, for 8 weeks. The clinical changes were evaluated, including xerostomia, the Oral Health Impact Profile 14 (OHIP-14) score, Pittsburg Sleep Quality Index, and the Hospital Anxiety and Depression Scale (HADS). Oxygen saturation and heart rate were recorded, with an analysis of salivary biomarkers in the forms of oxytocin, ferritin, adenosine deaminase (ADA), total proteins, and alpha-amylase. Results: a total of 64 patients were analyzed. A significant decrease in burning sensation was recorded with melatonin (7.8 ± 1.54 pre-treatment, 5.78 ± 2.54 post-treatment; p < 0.001) and clonazepam (8.75 ± 1.2 pre-treatment, 5.5 ± 3.6 post-treatment (p < 0.01). With regard to quality of life (OHIP-14), significant improvements were observed before and after the administration of melatonin (p < 0.001) and clonazepam (p = 0.001). On the other hand, with regard to the changes in salivary biomarkers following treatment, negative correlations were found between oxytocin and drainage (r = −0.410; p = 0.009) and between the HADS-D score and ferritin (r = −0.312; p = 0.05). While salivary amylase showed positive correlation with heart rate (r = 0.346; p = 0.029) and oxygen saturation (r = 0.419; p = 0.007). Conclusions: melatonin and clonazepam were shown to be effective at reducing the burning sensation and improving quality of life. Both drugs were found to be safe, with no major adverse effects in patients with BMS. Melatonin may be regarded as an alternative treatment for patients with BMS, though further studies are needed to confirm its effectiveness.

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A Study to Assess the Levels of Salivary Ferritin in Iron Deficiency Anemia Subjects and Healthy Subjects

Cited by 4 publications

References 14 publications

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

Effect of the Emotional Antisaccade Tasks on Salivary Trace Elements and Resting State EEG in Patients with Obsessive-Compulsive Disorder

Response to Treatment with Melatonin and Clonazepam versus Placebo in Patients with Burning Mouth Syndrome

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