A study to compare circulating flunixin, meloxicam and gabapentin concentrations with prostaglandin E2 levels in calves undergoing dehorning

Fraccaro, E.; Coetzee, Johann F.; Odore, R.; Edwards‐Callaway, Lily N.; KuKanich, Butch; Badino, P.; Bertolotti, Luigi; Glynn, H.; Dockweiler, J; Allen, K. A.; Bergamasco, L.

doi:10.1016/j.rvsc.2013.01.018

Cited by 50 publications

(55 citation statements)

References 41 publications

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“…Restraining or holding of horned animals may be associated with both human and animal safety issues. Therefore, horn buds of young calves normally removed to decrease the risk of injuries to farm workers or other animals [5] .…”

Section: Introductionmentioning

confidence: 99%

Boynuz Köreltme İşlemi Uygulanan Buzağılarda Pre-Emptive Uygulanan Dexketoprofen Trometamol’un Akut Kortizol, İnflamatuar Yanıt ve Oksidatif Stres Üzerine Olan Etkisi

Korkmaz¹,

Saritaş²,

Bülbül³

et al. 2015

Kafkas Univ Vet Fak Derg

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Section: Introductionmentioning

confidence: 99%

Boynuz Köreltme İşlemi Uygulanan Buzağılarda Pre-Emptive Uygulanan Dexketoprofen Trometamol’un Akut Kortizol, İnflamatuar Yanıt ve Oksidatif Stres Üzerine Olan Etkisi

Korkmaz¹,

Saritaş²,

Bülbül³

et al. 2015

Kafkas Univ Vet Fak Derg

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“…A recent study on cattle undergoing surgical dehorning had demonstrated an increase in plasma PGE 2 which was reduced significantly after treatment with flunixin (Fraccaro et al, 2013). Therefore, measurement of PGE 2 has the potential to be applied as one of the parameters in the assessment of pain caused by routine husbandry procedures.…”

Section: Prostaglandinsmentioning

confidence: 99%

Refining a ‘toolkit’ for objective assessment of pain and stress in ruminants

Othman¹

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Pain is a complex phenomenon, and to address pain management in animals, the presence of pain needs to be determined. Most studies assess the presence of pain based on the appraisal of either a single biomarker or a combination of a few parameters, which were often not examined simultaneously. In ruminants, measurements of cortisol and haptoglobin (Hp), and the assessment of behavioural changes have been the standard practice for this purpose. Nevertheless, there are still limitations in using these parameters, as they are also indicators of psychological stress, and can be misinterpreted as to indicate the presence of pain. Assessment of behavioural changes in ruminants can be difficult as prey animals conceal their experience of pain to avoid predators' attention.Therefore it is recommended that a reliable assessment tool be devised that includes a combination of various parameters to determine the presence of pain in ruminants in order to address pain management effectively.The primary aims of this study were to evaluate the conventional and contemporary biomarkers to determine the response of an animal to a noxious experience, and to refine a multi-parameter 'toolkit' that can be applied in assessing pain in ruminants. For these purposes, castration was used as a model of a common painful husbandry procedure that presumably evokes pain associated with the tissue injury.Merino cross lambs were assigned to two groups that were either surgically castrated or subjected to restraint stress (control). Castration was an open surgical technique without the provision of anaesthesia or analgesia. The conventional biomarkers estimated were plasma cortisol, Hp and betaendorphin (β-EP). The contemporary biomarkers measured were interleukin-6 (IL-6), substance P (SP), and prostaglandin E 2 (PGE 2 ). The peripheral leukocytes expression of IL-6 and proopiomelanocortin (POMC), the precursor of β-EP were also estimated. Behavioural changes were recorded to assess pain-related behaviour caused by the surgical procedure.Following treatment, the cortisol concentration in the castrated lambs was higher than control animals from ten minutes to two hours post-castration, indicative of the acute noxious experience associated with the surgical procedure. Surgical castration also caused a response in SP indicative of nociception and neurogenic inflammation, which was increased from 30 minutes and became significant eight hours following castration. The behavioural assessment showed that the castrated lambs demonstrated statue standing, a pain-like behaviour, from three to five hours post-castration, which were associated with the increase in SP, indicative of the pain sensitisation caused by the tissue injury. Increase in the systemic inflammatory mediators, the Hp and IL-6 were observed from ii day two, in which Hp remained significant until day four and resolved by day five. The IL-6 continued to increase over time, suggesting of an ongoing inflammatory response and inflammatory pain possibly until wound healing had occurre...

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“…Baseado nos dados comportamentais e parâmetros fisiológicos, diversos estudos têm demonstrado a preocupação de pesquisadores e da sociedade com o bem-estar animal devido a dor causada pelo trauma térmico, fazendo-se necessário a utilização de medicamentos sedativos, anestésicos, analgésicos e anti-inflamatórios durante e após o procedimento da descorna (FAULKNER;WEARY, 2000;VICKERS et al, 2005;DOHERTY et al, 2007;STILWELL et al, 2010;FIERHELLER et al, 2012;ESPINOZA et al, 2013;FRACCARO et al, 2013;BATES et al, 2015;CARAY et al, 2015 proliferação celular e a síntese de colágeno (ROCHA JÚNIOR et al, 2006;DE MORAES et al, 2013;FIÓRIO et al, 2013;CATÃO et al, 2016).…”

Section: Introductionunclassified

“…Nas lesões de primeiro grau ou superficiais, a cicatrização ocorre entre 3 a 4 dias sem deixar cicatrizes. Nas lesões de segundo grau a cicatrização ocorre em média entre 14 e 21 dias sem produção emprego de pasta cáustica (VICKERS et al, 2005;BROOM, 2008;STILWELL et al, 2009), a cauterização pelo calor utilizando ferro quente (GRAFF; SENN, 1999;GRONDAHL-NIELSON et al, 1999;FAULKNER;WEARY, 2000;VICKERS et al, 2005;DOHERTY et al, 2007;STILWELL et al, 2010;STILWELL et al, 2012;HENRICH et al, 2013;BATES et al, 2015;CARAY et al, 2015), a cauterização pelo frio -crio cirurgia (BENGTSSON et al, 1996) e a excisão do broto germinativo utilizando uma guilhotina ("scoop disbudding") (ESPINOZA et al, 2013;FRACCARO et al, 2013). Dentre todas estas técnicas a que mais se destacada por estar inserida no manejo rotineiro das propriedades leiteiras é cauterização pelo calor utilizando o ferro quente, tornando-se, portanto, um dos principais fatores da ocorrência de queimaduras em bezerros (GRONDAHL-NIELSON et al, 1999;GOTTARDO et al, 2011;VICKERS et al, 2005;COZZI et al, 2015).…”

Section: Introductionunclassified

“…Pesquisas determinaram que, independentemente da técnica utilizada, a descorna é uma experiência dolorosa e faz-se necessário a utilização de sedativo e anestésico local antes do procedimento bem como a utilização de anti-inflamatórios não esteroidais (AINEs) no pós descorna (GRONDAHL-NIELSON et al, 1999;FAULKNER;WEARY, 2000;BROOM, 2008;STILWELL et al, 2009;STILWELL et al, 2010;STILWELL et al, 2012;FRACCARO et al, 2013).…”

Section: Introductionunclassified

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<b>Efeitos da fototerapia no processo de cicatrização de queimaduras em bezerros</b>

Barbosa¹

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DEDICATÓRIAAo Mundo Espiritual, que sempre iluminou no caminhar.Ao meu filho Bernardo , por ser a razão do meu viver.Aos meus pais Bruno e Kátia, por todo amor, apoio e incentivo em todos os momentos da minha vida.Ao meu marido Felipe, pelo companheirismo e ajuda em todas as horas.À minha avó Maria Amélia, por ser meu maior exemplo de mulher e por todo apoio em todas as horas. . The results showed no statistical differences among the groups according to wound healing time, and to the type III collagen deposition. It was possible to conclude that phototherapies, in the proposed irradiation parameters, were efficient as zinc oxide ointment in the burn wound healing in calves. AGRADECIMENTOS

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A study to compare circulating flunixin, meloxicam and gabapentin concentrations with prostaglandin E2 levels in calves undergoing dehorning

Cited by 50 publications

References 41 publications

Boynuz Köreltme İşlemi Uygulanan Buzağılarda Pre-Emptive Uygulanan Dexketoprofen Trometamol’un Akut Kortizol, İnflamatuar Yanıt ve Oksidatif Stres Üzerine Olan Etkisi

Boynuz Köreltme İşlemi Uygulanan Buzağılarda Pre-Emptive Uygulanan Dexketoprofen Trometamol’un Akut Kortizol, İnflamatuar Yanıt ve Oksidatif Stres Üzerine Olan Etkisi

Refining a ‘toolkit’ for objective assessment of pain and stress in ruminants

<b>Efeitos da fototerapia no processo de cicatrização de queimaduras em bezerros</b>

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