A Study to derive distribution of carotid intima media thickness and to determine its COrrelation with cardiovascular Risk factors in asymptomatic nationwidE Indian population (SCORE-India)

Kasliwal, Ravi R; Pankaj, K. Agarwal; Arora, Parneesh; Bansal, Manish; Mahesh, B.A; Desai, Nagaraj; Vidyut, K. Jain; Ravi, R. Kasliwal; Kotak, Bhavesh; Kumar, Amit; Prathap, Kumar; Surender, Kumar; Mohannan, P.P.; Srinivas, R.; Raza, Ammar; Sudhir, Shraddha; Mahesh, Shah; Meena, Shetty; Singh, Uaday; Thanvi, Sunil; Vasnawala, Hardik

doi:10.1016/j.ihj.2016.04.009

Cited by 27 publications

(13 citation statements)

References 41 publications

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“…But a recent SCORE-India study highlights that the CIMT values were also higher in diabetic subjects at (0.635 ± 0.10 mm) as compared to nondiabetics (0.589 ± 0.12 mm). 30 Hence our observations are consistent with the above nationwide SCORE-India study. Our study shows that the mean CIMT in the silent MI positive group was 0.713 ± 0.021 mm as compared to 0.662 ± 0.028 mm in the negative group.…”

Section: Discussionsupporting

confidence: 91%

Prevalence and RIsk factors for Silent Myocardial ischemia (PRISM): A clinico observational study in patients of type 2 diabetes

Prasad

Kabir

Devi

et al. 2019

Indian Heart Journal

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Objectives To estimate the prevalence and to identify potential risk factors of silent myocardial ischemia in a cohort of patients with asymptomatic type 2 Diabetes (diabetes) for early detection of coronary risk by employing objective noninvasive clinical screening tools for Subclinical Atherosclerosis. Methods The study is a clinic-based observational study on 338 consecutive diabetes patients attending an urban health center from Eastern India. The response rate was 96.57% out of 350 eligible subjects, comprising 176 (52.1%) males and 162 (47.9%) females. Clinical, anthropometric, biochemical parameters were collected in all participants. Both tools, i.e., treadmill test (TMT) to identify subjects with silent myocardial ischemia, and carotid imaging to detect subclinical atherosclerosis by evaluating carotid intima-media thickness (CIMT), were assessed. Significant determinants were predicted by multivariable logistic regression. Results The study group was divided into a TMT negative ( n = 260), and a TMT positive group ( n = 78). These 78 TMT positive subjects (23.1%) were identified to have silent myocardial ischemia. The prevalence of silent myocardial ischemia was more common in males (28.4%) than in females (17.3%). The mean CIMT in our study group was 0.6741 ± 0.034 mm (males – 0.684 ± 0.034 mm and females – 0.663 ± 0.032 mm). Age ≥50 years, CIMT ≥0.70 mm, hypercholesterolemia, and hypertriglyceridemia were significant determinants for identifying asymptomatic diabetics at risk for silent myocardial ischemia. Conclusion Silent myocardial ischemia is highly prevalent at about one in four asymptomatic diabetic patients. An increased CIMT can be a surrogate marker of higher coronary risk amongst these asymptomatic diabetics.

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Section: Discussionsupporting

confidence: 91%

Prevalence and RIsk factors for Silent Myocardial ischemia (PRISM): A clinico observational study in patients of type 2 diabetes

Prasad

Kabir

Devi

et al. 2019

Indian Heart Journal

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“…Over more than two decades, CIMT has been extensively researched and established. Moreover, several large, research-based cohort studies have clearly indicated a relationship between CIMT and CV events 21, 22, 23, 24, 25, 26, 27, 28, 29. Carotid plaque, defined as a focal abnormal wall thickness (CIMT > 1.5 mm) or a focal thickening of >50% of the surrounding CIMT has been shown to be a more powerful predictor of CV risk compared with CIMT alone.…”

Section: The Role Of Cimt As Screening Techniquementioning

confidence: 99%

HIV related stigma, perceived social support and risk of premature atherosclerosis in South Asians

Bergmann

Sengupta

Bhrushundi

et al. 2018

Indian Heart Journal

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Objective This study sought to determine the association between social support and stigma experienced by HIV-positive patients and presence of subclinical cardiovascular disease. Methods We implemented a cross sectional study in 67 HIV-positive patients and 52 controls from a community health care center in central India. The participants underwent an in-depth survey and a clinical and laboratory assessment of cardiovascular risk. Carotid-intimal thickness (CIMT) was used as a marker of subclinical cardiovascular disease. Results On comparing the HIV and age and sex-matched control population, HIV patients had lower body weight (P=<0.001), and lower systolic blood pressures (P = 0.002). Despite the lack of higher cardiac risk factor prevalence and lower lipid abnormalities, HIV patients had higher right, left and average CIMT values than controls (P < 0.001 for all). HIV patients also showed higher prevalence of abnormal CIMT (≥ 0.9 mm) than controls (32% vs. 0%, P < 0.001). HIV patients with increased CIMT (n = 37) in comparison with those with normal CIMT (n = 30) were more frequently males (P = 0.023), had higher systolic blood pressures (P = 0.002), lower CD4 counts (P = 0.033) and experienced higher enacted stigma (P = 0.044). On multivariable stepwise logistic regression, systolic blood pressure (odds ratio:1.06, P = 0.002) and stigma score > 25 th percentile value (odds ratio:3.84, P = 0.037) were independent predictors of the abnormal CIMT. Conclusions HIV-positive patients from central India have a higher prevalence of abnormal CIMT as a marker of subclinical cardiovascular disease than the general population. This predisposition to increased cardiovascular risk may be related to complex interactions between HIV disease and stigma-related healthcare inequalities.

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“…The CIMT and aortic stiffness were high in cHypoPT patients with CAD and CAC, respectively. Interestingly, the CIMT value was above the cutoff of healthy Indians in only one cHypoPT with CAD 33 . CIMT did not correlate with serum total calcium or phosphorus at presentation or during follow‐up.…”

Section: Discussionmentioning

confidence: 82%

Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism

Saha

Narang

Goswami

et al. 2023

Clinical Endocrinology

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A Study to derive distribution of carotid intima media thickness and to determine its COrrelation with cardiovascular Risk factors in asymptomatic nationwidE Indian population (SCORE-India)

Abstract: This is the first study to provide age- and gender-specific distribution of CIMT in Indian subjects free from CVD. This information should help facilitate further research and clinical work involving CIMT in India.

Cited by 27 publications

References 41 publications

Prevalence and RIsk factors for Silent Myocardial ischemia (PRISM): A clinico observational study in patients of type 2 diabetes

Prevalence and RIsk factors for Silent Myocardial ischemia (PRISM): A clinico observational study in patients of type 2 diabetes

HIV related stigma, perceived social support and risk of premature atherosclerosis in South Asians

Coronary artery disease and its vascular associates in patients with chronic nonsurgical hypoparathyroidism

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