A subchronic toxicity study, preceded by an in utero exposure phase, with refined arachidonic acid-rich oil (RAO) derived from Mortierella alpina XM027 in rats

Gao, Yonglin; Li, Chunmei; Kang, Le; Hang, Bing; Yan, Mengjun; Li, Shenjun; Huang, Jin; Lee, Albert W.; Cho, Susan S.

doi:10.1016/j.yrtph.2014.10.009

Cited by 10 publications

(2 citation statements)

References 15 publications

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“…Organ weight changes have long been considered a sensitive marker of chemically induced organ damage [21]. In the present study, elevated absolute and relative uterus weights were observed in all yonkenafil-treated groups.…”

Section: Journal Of Biomedical Sciences Issn 2254-609xsupporting

confidence: 62%

“…According to the toxicokinetic results, these differences may due to gender differences in drug metabolism. Other PDE5 inhibitors, such as sildenafil, vardenafil and avanafil, undergo hepatic metabolism via the CYP3A4 pathway, but no gender difference was reported [21][22][23]. Thus, further research is needed concerning the mechanism of action and metabolism of yonkenafil hydrochloride.…”

Section: Journal Of Biomedical Sciences Issn 2254-609xmentioning

confidence: 99%

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A 90-day Repeat-Dose Oral Toxicity Study of Yonkenafil Hydrochloride in Beagle Dogs

Liu¹,

Jin²,

Yu³

et al. 2017

J Biomedical Sci

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Yonkenafil hydrochloride, a novel synthetic phosphodiesterase type 5 inhibitor, is a promising drug for the treatment of erectile dysfunction. The repeated-dose toxicity of yonkenafil hydrochloride was assessed in male and female beagle dogs. Twenty-four dogs were randomly allocated to four groups and administered yonkenafil hydrochloride orally at dosages of 0, 7, 30 or 120 mg/kg/day for 90 days followed by a 28-day recovery period. During the test period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, electrocardiography, hematology, serum biochemistry, urinalysis, organ weights, gross findings and histopathology were examined. There were no abnormal changes in the clinical observations except that gastrointestinal intolerance was observed in the 120 mg/kg/day group. The laboratory and histopathological examinations revealed yonkenafil hydrochloride toxicity to various organs, including the thyroid gland, liver, prostate, uterus and breast; at the end of the recovery period, this damage was resolved. The level of yonkenafil hydrochloride that resulted in no observable adverse effects in beagle dogs was 7 mg/kg/day.

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Section: Journal Of Biomedical Sciences Issn 2254-609xsupporting

confidence: 62%

Section: Journal Of Biomedical Sciences Issn 2254-609xmentioning

confidence: 99%

A 90-day Repeat-Dose Oral Toxicity Study of Yonkenafil Hydrochloride in Beagle Dogs

Liu¹,

Jin²,

Yu³

et al. 2017

J Biomedical Sci

View full text Add to dashboard Cite

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Application of organic acids for plant protection against phytopathogens

Morgunov

Kamzolova

Dedyukhina

et al. 2016

Appl Microbiol Biotechnol

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The basic tendency in the field of plant protection concerns with reducing the use of pesticides and their replacement by environmentally acceptable biological preparations. The most promising approach to plant protection is application of microbial metabolites. In the last years, bactericidal, fungicidal, and nematodocidal activities were revealed for citric, succinic, α-ketoglutaric, palmitoleic, and other organic acids. It was shown that application of carboxylic acids resulted in acceleration of plant development and the yield increase. Of special interest is the use of arachidonic acid in very low concentrations as an inductor (elicitor) of protective functions in plants. The bottleneck in practical applications of these simple, nontoxic, and moderately priced preparations is the absence of industrial production of the mentioned organic acids of required quality since even small contaminations of synthetic preparations decrease their quality and make them dangerous for ecology and toxic for plants, animals, and human. This review gives a general conception on the use of organic acids for plant protection against the most dangerous pathogens and pests, as well as focuses on microbiological processes for production of these microbial metabolites of high quality from available, inexpensive, and renewable substrates.

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Microbial polyunsaturated fatty acids (PUFAs) for human health: A comprehensive review of evidence from in vivo preclinical models

Mukherjee,

Mohanty,

Rao

et al. 2024

Discov Appl Sci

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A subchronic toxicity study, preceded by an in utero exposure phase, with refined arachidonic acid-rich oil (RAO) derived from Mortierella alpina XM027 in rats

Cited by 10 publications

References 15 publications

A 90-day Repeat-Dose Oral Toxicity Study of Yonkenafil Hydrochloride in Beagle Dogs

A 90-day Repeat-Dose Oral Toxicity Study of Yonkenafil Hydrochloride in Beagle Dogs

Application of organic acids for plant protection against phytopathogens

Microbial polyunsaturated fatty acids (PUFAs) for human health: A comprehensive review of evidence from in vivo preclinical models

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