A subhypnotic dose of ketamine reduces pain associated with injection of propofol and rocuronium

Abduşoğlu, Mustafa; Özkoçak, Işıl; Yurtlu, Serhan; Hanc, Volkan; Okyay, Rahşan Dilek; Ayoğlu, Hilal

doi:10.1097/eja.0b013e3283425603

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…Though injection pain is not a life-threatening complication of anesthesia, it remains an unpleasant situation associated with anesthesia in the minds of patients [3]. Methods such as the use of small doses of medications like iv lidocaine, ketamine, opioids and nonsteroidal anti-inflammatory drugs (NSAID) before propofol injection and diluting the propofol solution have been tried and used to prevent injection pain [4,5]. Preemptive analgesia is an analgesia method with the aim of postoperative pain control with analgesic administered before pain forms due to the surgical stimuli and which reduces the severity of pain and the requirements for analgesic agents [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Preemptive Intravenous Ibuprofen on propofol Injection Pain

Taş¹

2018

JAICM

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The aim of this study is to show whether intravenous ibuprofen administered is effective in preventing propofol injection pain. Methods and Material:The study included 120 adult patients. Patients in the ibuprofen group were administered 400 mg ibuprofen as intravenous infusion. Patients in the control group were administered physiologic serum, while patients in the lidocaine group were administered 2% lidocaine intravenously. After 30 seconds the tourniquet was released and ¼ of the propofol dosage necessary for induction was administered. Then pain in the arm was questioned and arm pull reactions were assessed. Statistical analysis used: The Chi-square test or Fisher's exact test, Student -t test and the one way ANOVA test were used.Results: In Group C there was no patient with pain score of 0, while this rate was 70% in Group L and 20% in Group I (p<0.05). In 52.5% of patients in Group I there was mild pain observed, and this result was found to be significantly high compared to Group C and Group L (p<0.001). In Group C the number of patients feeling moderate and severe levels of pain was significantly high compared with Group L and Group I (p<0.001, p<0.05). In terms of arm pull reactions 85% of patients in Group L and 70% of patients in Group I had no reaction observed, and this result was significantly high compared to Group C (17.5%) (p<0.001).Conclusions: 400 mg ibuprofen administered had positive effect on reducing propofol injection pain.

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Section: Introductionmentioning

confidence: 99%

Effect of Preemptive Intravenous Ibuprofen on propofol Injection Pain

Taş¹

2018

JAICM

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Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults

Prabhakar

Singh

Ali³

et al. 2016

Cochrane Database of Systematic Reviews

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Pharmacological prevention of rocuronium-induced injection pain or withdrawal movements: a meta-analysis

Kwak

Kim

et al. 2013

J Anesth

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Rocuronium is reported to be associated with injection pain or withdrawal movement (IPWM). This meta-analysis assessed the efficacy of different pharmacological treatments used to decrease the incidence of the rocuronium-induced IPWM. We searched the Cochrane Library, Embase and PubMed for randomized controlled trials comparing a pharmacological drug with a placebo to prevent the rocuronium-induced IPWM and found 37 studies with 5,595 patients. Overall incidence of rocuronium-induced IPWM was 74%. Pretreatment with opioids [risk ratio (RR) 0.16; 95% confidence interval (95% CI) 0.09-0.29], lidocaine (0.47; 0.35-0.64), and ketamine (0.41; 0.22-0.77) were effective in decreasing IPWM. Lidocaine pretreatment with venous occlusion (0.40; 0.32-0.49) and opioids pretreatment with venous occlusion (0.77; 0.61-0.96) were also effective. Mixing sodium bicarbonate (NaHCO3) with rocuronium (0.15; 0.06-0.34) was also efficacious in reducing IPWM. Indirect comparison shows that the RR of NaHCO3 admixture and pretreatment with opioids were lower than that of the other four interventions (pretreatments of ketamine or lidocaine, and lidocaine or opioids with venous occlusion). This meta-analysis suggests that opioids, lidocaine, ketamine, and NaHCO3 are effective in decreasing rocuronium-induced IPWM. Considering the efficacy and convenience, pretreatment with opioids without venous occlusion is recommended for reducing rocuronium-induced IPWM.

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A subhypnotic dose of ketamine reduces pain associated with injection of propofol and rocuronium

Cited by 7 publications

References 6 publications

Effect of Preemptive Intravenous Ibuprofen on propofol Injection Pain

Effect of Preemptive Intravenous Ibuprofen on propofol Injection Pain

Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults

Pharmacological prevention of rocuronium-induced injection pain or withdrawal movements: a meta-analysis

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