A substrate protection approach to applying the calcium ion for improving the proteolysis resistance of the collagen

Gao, Mengchu; Tian, Yongxin; Zhang, Xu; Zhang, Chunxiao; Peng, Biyu

doi:10.1007/s00253-021-11704-1

Cited by 8 publications

(4 citation statements)

References 50 publications

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“…Similar results of thermal stabilities of the processed leather were also observed in other studies conducted previously by Gao et al [52]. Calcium ions might have a positive contribution in stabilizing the collagen structure in the hide which ultimately facilitated the crosslinking between chromium ions and collagen fibres leading to the formation of more durable and stable finished leather [52].…”

Section: Thermogravimetric Analysis (Tga) Of Leather Samplessupporting

confidence: 84%

“…Calcium ions might have also played a significant role in stabilizing the collagen structures in the hide. This process of stabilization might have facilitated the formation of the crosslinking between chromium ions and collagen fibres which eventually led to the manufacturing of more durable and stable leather products [52]. The findings of the TGA analysis of the goat leather samples that had been tanned using recovered basic chromium sulfate solutions were in good agreement with the significant outcomes of the SEM analysis of the corresponding leather sample A.…”

Section: Fibre Structure Analysis By Fesem (Field Emission Scanning E...supporting

confidence: 66%

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Recovery and Reuse of Chromium from Tan Yard Solid Waste in Leather Manufacturing

Mottalib,

Chandra,

Naher

et al. 2023

Text Leather Rev

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Chrome tanning is the most popular and widely used method utilizing basic chromium salts in leather processing. Only 60-70% of these salts react with collagen to form leather. The rest remains unreacted being released as toxic waste and causing severe environmental pollution in many developing countries. In the current study, a significant approach was made to utilize solid waste with a clean environment perspective. The chromium was extracted as basic chromium sulfate using H2SO4 from tannery waste and reused in the leather manufacturing procedure. Extracted solid sludge was examined by Atomic Absorption Spectrometry and elemental analysis before and after the separation of chromium (III). It revealed that 97% of chromium was extracted from tan yard sludge. Recovered chromium sulfate was reused in goat skin processing. Batch experiments were carried out by applying recovered basic chromium sulfate, and a combination of fresh and recovered basic chromium sulfate solutions separately. Fresh basic chromium sulfate was used as the control method. The structure and morphology of the final processed leather were characterized by Field Emission Scanning Electron Microscope (FESEM) and Thermogravimetric analysis (TGA). The identical structural morphologies of all processed leather were confirmed in the FESEM study. The physical and chemical characteristics of all finished leather were found very similar. The TGA analysis data proved that raw leather processed by recovered chromium is thermally more stable than others. These research findings signify a new potential effort of separating important chemicals from solid sludge and reusing them. This technique is simple, cost-effective, eco-friendly, and sustainable as it reduces environmental pollution from tannery chromium waste.

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Section: Thermogravimetric Analysis (Tga) Of Leather Samplessupporting

confidence: 84%

Section: Fibre Structure Analysis By Fesem (Field Emission Scanning E...supporting

confidence: 66%

Recovery and Reuse of Chromium from Tan Yard Solid Waste in Leather Manufacturing

Mottalib,

Chandra,

Naher

et al. 2023

Text Leather Rev

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“…[ 53 ] The a‐band with the lowest electrostatic potential energy was the most favorable region for mineral precursors entering into collagen fibrils when collagen fibrils interplayed with the negatively charged ACP nanoparticles. [ 53 ] Alkaline environment could promote the dissociation of carboxyl groups of collagen fibrils [ 61 ] and enhance their electronegativity. [ 62 ] However, the amino acid residues containing carboxyl groups are limited that only account for about 11% of the collagen fibrils.…”

Section: Resultsmentioning

confidence: 99%

Citrate Improves Biomimetic Mineralization Induced by Polyelectrolyte–Cation Complexes Using PAsp‐Ca&Mg Complexes

Shen,

Xu,

et al. 2024

Adv Healthcare Materials

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Magnesium ions are highly enriched in early stage of biological mineralization of hard tissues. Paradoxically, hydroxyapatite (HAp) crystallization is inhibited significantly by high concentration of magnesium ions. The mechanism to regulate magnesium‐doped biomimetic mineralization of collagen fibrils has never been fully elucidated. Herein, we revealed that citrate could bio‐inspire the magnesium‐stabilized mineral precursors to generate magnesium‐doped biomimetic mineralization as follows: Citrate could enhance the electronegativity of collagen fibrils by its absorption to fibrils via hydrogen bonds. Afterward, electronegative collagen fibrils could attract highly‐concentrated electropositive polyaspartic acid‐Ca&Mg (PAsp‐Ca&Mg) complexes followed by phosphate solution via strong electrostatic attraction. In the meanwhile, citrate adsorbed in/on fibrils could eliminate mineralization inhibitory effects of magnesium ions by breaking hydration layer surrounding magnesium ions and thus reduce dehydration energy barrier for rapid fulfillment of biomimetic mineralization. The remineralized demineralized dentin with magnesium‐doped HAp possessed antibacterial ability and the mineralization mediums possessed excellent biocompatibility via cytotoxicity and oral mucosa irritation tests. This strategy should shed light on cationic ions‐doped biomimetic mineralization with antibacterial ability via modifying collagen fibrils and eliminating mineralization inhibitory effects of some cationic ions, as well as could excite attention to the neglected multiple regulations of small biomolecules, such as citrate, during biomineralization process.This article is protected by copyright. All rights reserved

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“…Gao et al also reported that Ca 2+ could widen the distance between fibers and disperse fibers, but Ca 2+ also could make fibers swell and expand. 32 Na 2 SO 4 obviously promoted collagen aggregation owing to clustered intermolecular salt bridges formed between collagen molecules and the weakened electrostatic repulsions by binding of SO 4 2-. Na 2 SO 4 induced collagen to aggregate tightly, which could make water between collagen move outward, so Na 2 SO 4 could dehydrate collagen fibers and fiber bundles.…”

Section: Radial Distribution Function Analysismentioning

confidence: 99%

Study on Interaction Mechanism between Neutral Salts and Collagen by Combining Experiments with Molecular Dynamics Simulation

Gu,

Zhang,

Zhang

et al. 2023

JALCA

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The effect of salt on the collagen of hide/skin is of great significance in leather-making. However, the interaction between neutral salts and collagen has not been clear, since the microscopic interaction is hard to be observed directly from the macro level of hide/skin collagen. In this study, the collagen solutions in the typical neutral salts (NaCl, CaCl2, and Na2SO4) systems were used to explore the interaction mechanism between neutral salts and collagen via combining experiments with molecular dynamics (MD) simulation. The results of fluorescence measurements of pyrene, dynamic light scattering, atomic force microscopy, and isoelectric point suggested that the variation of the interaction between different neutral salts and collagen was accompanied with the changes in physicochemical properties of collagen. MD simulation further revealed more detailed information on the interaction mechanism between neutral salts and collagen at the molecular level. The computational results of non-bond energy of the collagen-salt model boxes indicated that the electrostatic interactions of different salts with collagen molecules had the order of CaCl2> Na2SO4> NaCl. The analyses of the visualized conformation and the radial distribution functions showed that CaCl2 with Ca2+ as contributing ion tended to form intramolecular salt bridges with collagen, while Na2SO4 with SO42-as contributing ion more likely formed salt bridges between collagen molecules in the shape of agglomerates. In contrast, NaCl with Cl-as contributing ion was scattered around the collagen models, and its effect on collagen was much smaller. The study elaborated the interaction mechanism of typical neutral salts and collagen to be helpful for further understanding and improving the use of neutral salts in many steps involved in leather production.

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A substrate protection approach to applying the calcium ion for improving the proteolysis resistance of the collagen

Cited by 8 publications

References 50 publications

Recovery and Reuse of Chromium from Tan Yard Solid Waste in Leather Manufacturing

Recovery and Reuse of Chromium from Tan Yard Solid Waste in Leather Manufacturing

Citrate Improves Biomimetic Mineralization Induced by Polyelectrolyte–Cation Complexes Using PAsp‐Ca&Mg Complexes

Study on Interaction Mechanism between Neutral Salts and Collagen by Combining Experiments with Molecular Dynamics Simulation

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