Objectives
We sought to assess consent rates for organ donation from potential brain-dead donors, and to identify factors associated with variation in consent for donation that could guide the development of targeted interventions to increase organ consent rates.
Design, Setting, and Subjects
We used data provided by the Organ Procurement and Transplantation Network (OPTN) to analyze the 35,823 OPO-reported eligible deaths (potential brain-dead donors ≤70 years of age) from January 1st, 2008 to October 31st, 2011.
Measurements and Main Results
Excluding cases where donation authorization was based on prior patient documentation (e.g. donor registry), consent was obtained on 21,601 (68.9%), not obtained on 8,727 (27.8%), and not requested on 1,080 (3.4%) eligible deaths. There were substantial differences in consent rates among racial/ethnic groups (77.0% in whites, 67.5% in Hispanics, 54.9% in blacks, and 48.1% in Asians) and OPOs (median (IQR): 72.4% (67.5 – 87.3)). In generalized estimating equation models, with whites and patients ages 18–39 years as the respective reference groups, consent for donation was less likely to be obtained among Hispanics (OR 0.54; 95% CI: 0.44–0.65), blacks (OR 0.35; 95% CI: 0.31–0.39), Asians (OR 0.31; 95% CI: 0.25–0.37), and eligible donors ages 55–64 (OR 0.72; 95% CI: 0.67–0.77), and ≥ 65 (OR 0.58; 95% CI: 0.52–0.64) years.
Conclusions
In presenting the first published analyses of consent rates among all eligible deaths, this study confirms smaller and regional studies that showed significant differences in consent rates between whites and racial/ethnic minorities (blacks, Hispanics, and Asians). The study also identifies considerable variation in consent rates between age groups and between OPOs. Critical care physicians are usually the front-line providers for potential brain-dead donors and their next-of-kin, and these data highlight the need for further research to identify the causes of variation in consent rates and mechanisms to increase rates where appropriate.