A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway

Jiang, Yan; Pan, Yong; Rhea, Patrea R.; Tan, Lin; Gagea, Mihai; Cohen, Lorenzo; Fischer, Susan M.; Yang, Peiying

doi:10.1158/0008-5472.can-14-3432

Cited by 77 publications

(70 citation statements)

References 33 publications

(32 reference statements)

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“…Panc-02 cells injected orthotopically into the pancreases of syngeneic C57BL/6 (B6) mice can form hepatic metastases (25), and 4T1 breast cancer cells injected orthotopically into the mammary fat pads of syngeneic BALB/c female mice can form lung metastases (26,27). Panc-02 cells stably transfected with PPARD-shRNA-A (PPARD-shRNA-A-clone1 or -clone2) had significantly lower PPARD RNA and protein expression than did WT Panc-02 cells and Panc-02 cells transfected with control-shRNA (Supplemental Figure 3, A removed when it reached a predetermined size of 10 mm in the greatest diameter (Figure 4, E and G).…”

Section: Ppard Expression In Cancer Cells Is Critical To Metastasis Fmentioning

confidence: 99%

Metastasis regulation by PPARD expression in cancer cells

Zuo¹,

Xu²,

Xu³

et al. 2017

JCI Insight

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Section: Ppard Expression In Cancer Cells Is Critical To Metastasis Fmentioning

confidence: 99%

Metastasis regulation by PPARD expression in cancer cells

Zuo¹,

Xu²,

Xu³

et al. 2017

JCI Insight

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“…The challenges of the catabolism of sugars other than glucose may be widespread. For example, in humans, bypassing glucose-responsive regulatory mechanisms with fructose has been associated with diabetes (Lê et al, 2009; Kolderup and Svihus, 2015) and cancer (Port et al, 2012; Jiang et al, 2016). …”

Section: Discussionmentioning

confidence: 99%

Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network

Kuang

Hutchins

Russell

et al. 2016

eLife

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The evolutionary mechanisms leading to duplicate gene retention are well understood, but the long-term impacts of paralog differentiation on the regulation of metabolism remain underappreciated. Here we experimentally dissect the functions of two pairs of ancient paralogs of the GALactose sugar utilization network in two yeast species. We show that the Saccharomyces uvarum network is more active, even as over-induction is prevented by a second co-repressor that the model yeast Saccharomyces cerevisiae lacks. Surprisingly, removal of this repression system leads to a strong growth arrest, likely due to overly rapid galactose catabolism and metabolic overload. Alternative sugars, such as fructose, circumvent metabolic control systems and exacerbate this phenotype. We further show that S. cerevisiae experiences homologous metabolic constraints that are subtler due to how the paralogs have diversified. These results show how the functional differentiation of paralogs continues to shape regulatory network architectures and metabolic strategies long after initial preservation.DOI: http://dx.doi.org/10.7554/eLife.19027.001

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“…30,31 Clinical research is hindered by the variability in diets and the associated metabolic interactions that may occur when trying to study the effects of specific macronutrients. Weight and physical activity can also confound results of dietary studies.…”

Section: Fatsmentioning

confidence: 99%

Lifestyle modifications for patients with breast cancer to improve prognosis and optimize overall health

Hamer

Warner

2017

CMAJ

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A lthough more than 90% of patients with breast cancer have early stage disease at diagnosis, about 25% will eventually die of distant metastasis.1 Many patients with breast cancer seek information from a variety of sources about behaviours that may reduce their risk of recurrence.2 Making positive lifestyle changes can also be psychologically beneficial to patients by empowering them, since the feeling of loss of control is one of biggest challenges of a cancer diagnosis.In this review, we identify which lifestyle changes can be recommended to patients as an adjunct to standard breast cancer treatments, to reduce their risk of distant recurrence and death. We review the role of lifestyle factors, particularly weight management, exercise, diet, smoking, alcohol intake and vitamin supplementation, on the prognosis of patients with breast cancer. Our literature search is summarized in Box 1.It is challenging to study lifestyle factors independently, because patients who are more physically active often are leaner, eat a healthier diet and are typically less likely to drink excessive amounts of alcohol or smoke; however, many studies try to adjust for these confounders.3 Another limitation is the potential impact of lifestyle factors before diagnosis. 4 Regrettably, but understandably, we found very few randomized trials. How does body weight influence the prognosis for breast cancer?Women who gain weight during or after treatment of breast cancer have been consistently shown to be at higher risk of breast cancer-related death.5-7 Also, women who are overweight or obese at the time of diagnosis have a poorer prognosis.8 Proposed mechanisms of how obesity might affect breast cancer mortality include a rise in circulating insulin-like growth factor, elevated circulating sex hormones and production of proinflammatory cytokines.9-12 Another possible mechanism is metabolic syndrome (presence of at least three of the following five components: abdominal obesity, hypertension, low level of highdensity lipoproteins, high plasma glucose level and high triglyceride levels). 13 In a recent study involving early stage breast cancer survivors, patients with metabolic syndrome were at significantly increased risk of distant metastasis (hazard ratio [HR] 2.45, 95% confidence interval [CI] 1.24-4.82) compared with those without the syndrome. 13Most patients with breast cancer gain weight both during and after active treatment, and much of the weight is never lost. The average reported weight gain is 2.5-5 kg, 5 but a gain of 10 kg or more is not uncommon.14 The reasons for weight gain are multifactorial and include "stress eating," reduced activity because of fatigue or other treatment-related adverse effects, lowered metabolic rate from chemotherapy, and use of pre-and post-chemotherapy medications such as dexamethasone.14 Weight gain is most common in women who experience treatment-related menopause and is often accompanied by relative fat gain and muscle loss. 15Several observational studies have shown that gaining weight dur...

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A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway

Cited by 77 publications

References 33 publications

Metastasis regulation by PPARD expression in cancer cells

Metastasis regulation by PPARD expression in cancer cells

Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network

Lifestyle modifications for patients with breast cancer to improve prognosis and optimize overall health

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