A suggested framework for conducting esophageal cancer screening in China

Abstract

Esophageal cancer is one of the most prevalent malignant tumors worldwide. Because of its challenging clinical characteristics, esophageal cancer is a major disease burden on the economy, society, and individuals. There is an urgent need to establish a beneficial policy to reduce the burden and to improve the health‐related quality of life of patients. Primary prevention with smoking cessation and reduction of drinking alcohol are highly recommended. Screening, early diagnosis and treatment are suggested. This study intended to establish a modified future screening model from the social perspective that deploys different strategies for different populations. Risk assessment and community‐based screening are proposed for high‐risk populations. Health education in low‐risk areas could help promote primary prevention to mitigate lifestyle factors and to increase public awareness and potentially to increase screening and early detection.

Low STMN1 is associated with better prognosis in Asian patients with esophageal cancers: a meta-analysis

“…The poor prognosis of esophageal cancer is often associated with invasiveness and metastasis [ 1,11].…”

“…Esophageal cancer is a common malignant tumor of the digestive system, with high morbidity and mortality that severely threatens the health and the quality of life of patients [ 1]. Esophageal cancer includes esophageal squamous cell carcinoma and esophageal adenocarcinoma; the esophageal squamous cell carcinoma is the most common type in esophageal cancers [ 1]. Invasion and metastasis are the primary causes of esophageal cancer-related deaths and the key factors threatening the survival of these patients [ 2].…”

“…In recent years, STMN1 has been reported to promote the metastasis of bladder cancer, gastric cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, and sarcoma [ 5,6]. However, the impact of STMN1 on the prognosis of esophageal cancer is yet under investigation, albeit the prognosis of esophageal cancer is closely related to the degree of tumor differentiation, staging, and complication [ 1]. Poor prognosis of esophageal cancer is often associated with invasiveness and metastasis.…”

Modeling the Cost-effectiveness of Esophageal Cancer Screening in China

“…EC screening resulted in marked clinical benefits. First, the early diagnosis rates reached 70.59% to 98.1% [14]. In particular, a 10-year cohort study demonstrated decreased cumulative mortality (3.35% vs 5.05%) and cumulative incidence (4.17% vs 5.92%) in the screening population compared to the nonscreening population [15].…”

Modeling the Cost-effectiveness of Esophageal Cancer Screening in China

“…EC screening resulted in marked clinical bene ts. First, the early diagnosis rates reached 70.59% to 98.1% (14). In particular, a 10-year cohort study demonstrated decreased cumulative mortality (3.35% vs 5.05%) and cumulative incidence (4.17% vs 5.92%) in the screening population compared to the nonscreening population (15).…”