A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen

Tansakul, Natthasit; Niedorf, Frank; Kietzmann, Manfred

doi:10.1080/02652030601182870

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…One chicken was randomly selected as the blank control group and the other two chickens received nine antimicrobials. Dosage, time of administration, and time point of slaughter [ 36 , 37 , 38 , 39 ] are shown in Table 5 .…”

Section: Methodsmentioning

confidence: 99%

Quick Multi-Class Determination of Residues of Antimicrobial Veterinary Drugs in Animal Muscle by LC-MS/MS

Zhang

et al. 2018

Molecules

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On the basis of the highly sensitive and selective liquid chromatography-tandem mass spectrometry technique, a generic extraction solvent and a sample dilution method was developed for the residue analysis of different polar veterinary drugs known as fluoroquinolones, sulfonamides, macrolides, and tiamulin in chicken muscle. The results showed that the matrix-matched calibration curves of all 10 compounds were in an effective linear relationship (r2 ≥ 0.997) in the range of 0.2–100 μg L−1. At three spiking levels of 2 (5), 50, and 100 μg kg−1, average recoveries of analytes were between 67.1% and 96.6% with relative standard deviations of intra-day and inter-day below 20%. The limits of detection and limits of quantification of the method were in the range of 0.3–2.0 μg kg−1 and 2.0–5.0 μg kg−1, respectively, which were significantly lower than their maximum residue limits. In addition, the intensity of the target analytes and its corresponding matrix effects were obviously related to the sample dilution times (matrix concentration). There were no significant differences (p > 0.05) in the average content of almost any of the analytes in medicated chickens between this method and the method in the literature for determining analytes. Lastly, the proposed method was successfully applied for the simultaneous analysis of 10 common veterinary drugs in food animal muscle tissues.

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Section: Methodsmentioning

confidence: 99%

Quick Multi-Class Determination of Residues of Antimicrobial Veterinary Drugs in Animal Muscle by LC-MS/MS

Zhang

et al. 2018

Molecules

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“…In poultry, the most common route of administration is oral, in feed or water. Residues generally appear to persist longer in egg yolk that albumen (Table 8), although sulfonamides are initially deposited at higher concentrations in the albumen compared with the yolk following treatment (Romvary & Simon, 1992; Atta & El‐zeini, 2001; Roudaut & Garnier, 2002; Tansakul et al. , 2007).…”

Section: Overview Of the Drug Classesmentioning

confidence: 99%

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Goetting¹,

Lee²,

Tell³

2011

Journal of Veterinary Pharmacology and Therapeutics

151

135

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Goetting, V., Lee, K. A., Tell, L. A. Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature. J. vet. Pharmacol. Therap.34, 521–556. Poultry treated with pharmaceutical products can produce eggs contaminated with drug residues. Such residues could pose a risk to consumer health. The following is a review of the information available in the literature regarding drug pharmacokinetics in laying hens, and the deposition of drugs into eggs of poultry species, primarily chickens. The available data suggest that, when administered to laying hens, a wide variety of drugs leave detectable residues in eggs laid days to weeks after the cessation of treatment.

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“…Via fitting of the available experimental data for: sulfadimidine, oxolinic acid, clazuril, sulfaquinoxaline, sulfanilamide, pyrimethamine, and salicylic acid (Blom, 1975a;Roudaut, 1998;Tansakul et al, 2007;Giorgi & Soldani, 2008;Po zniak et al, 2015), values for Kw and Ky could be determined (Table 1). As an example, Fig.…”

Section: Resultsmentioning

confidence: 99%

Prediction of the residue levels of drugs in eggs, using physicochemical properties and their influence on passive diffusion processes

Schefferlie

Hekman

2016

Vet Pharm & Therapeutics

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Based on a physiologically based pharmacokinetic model, describing the relationship between the plasma concentration of a drug and its deposition into eggs, general transport constants into yolk and albumen were derived, for a number of compounds, using experimental data from literature. Using only generally accepted concepts in passive diffusion theory, these transport constants were used to derive and calibrate general equations, describing the transport into yolk and albumen, in terms of the physicochemical properties of a drug. It is shown that, in theory, it is possible to calculate/predict the transport constants, using the physicochemical parameters: pKa and plasma protein binding. For a number of sulfonamides, the model was used to predict their distribution between egg yolk and albumen; the outcome was compared to data found in literature. Within this dataset, the lipophilic nature of a drug does not seem to play a major role in explaining the distribution ratio of a drug between albumen and yolk.

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A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen

Cited by 10 publications

References 16 publications

Quick Multi-Class Determination of Residues of Antimicrobial Veterinary Drugs in Animal Muscle by LC-MS/MS

Quick Multi-Class Determination of Residues of Antimicrobial Veterinary Drugs in Animal Muscle by LC-MS/MS

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Prediction of the residue levels of drugs in eggs, using physicochemical properties and their influence on passive diffusion processes

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