A sulphated kaempferol 7,4′-dimethyl ether and a quercetin isoferulylglucuronide from the flowers of Tamarix aphylla

El-Ansari, Mohamed A.; Nawwar, Mahmoud A.M.; Dein, Alei El; Sherbeiny, A. E. A. El; Sissi, H. I. El

doi:10.1016/s0031-9422(00)89100-1

Cited by 28 publications

(7 citation statements)

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“…Preliminary TLC test revealed the presence of flavonoids in both T. aphylla AE and EE, which was previously described by other researches [ 6 ]. The main identified volatile principle, 6,10,14-trimethyl-2-pentadecanone, is a nonaromatic oxygenated hydrocarbon (ketone) and has a slightly fatty aroma with reported antimicrobial [ 20 ] and antioxidant [ 21 ] properties.…”

Section: Discussionsupporting

confidence: 76%

“…Also, T. africana shoot extract inhibited the growth of A-549 lung carcinoma cells, with an IC 50 value of 34 μ g/mL [ 26 ]. Previous reports of phytochemical screening of T. aphylla revealed its high content of flavonoids, polyphenols, and tannins [ 3 , 6 , 8 ]. Several phenolic compounds isolated from Tamaricaceae were tested for their cytotoxic effects against different cancer cell lines and were shown to exhibit cytotoxic potentials [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have recognized the various types of secondary metabolites present in T. aphylla . Reports had identified the presence of flavonoids [ 6 ], phenolics [ 7 ], hydrolysable tannins [ 3 ], and alkaloids [ 7 , 8 ] in the plant various extracts. Earlier investigations on the effects of T. aphylla on biological systems had revealed its insect growth inhibitory activity due to presence of ellagic acid [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Potential Antiproliferative Activity and Evaluation of Essential Oil Composition of the Aerial Parts of Tamarix aphylla (L.) H.Karst.: A Wild Grown Medicinal Plant in Jordan

Alhourani

Kasabri

Bustanji

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Essential (volatile) oil from aerial parts of Tamarix aphylla (L.) H.Karst. (Tamaricaceae) grown wild in Jordan was hydrodistilled by Clevenger apparatus and analyzed by means of GC and GC-MS techniques. In vitro screening of potential cytotoxicity of the aqueous (AE) and ethanol (EE) extracts was also evaluated against human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (Caco-2), and pancreatic carcinoma (Panc-1) cancer cell lines as well as normal human fibroblasts. GC-MS analysis of T. aphylla EO revealed its richness in nonterpenoid nonaromatic hydrocarbons (52.39%), with predominance of 6,10,14-trimethyl-2-pentadecanone as the principal component. Biologically, the plant extracts exhibited cytotoxicity effects in dose-dependent manner against most of the tested cell lines, but potent effects were only predicted against MCF-7 cells with IC50 values of 2.17 ± 0.10 and 26.65 ± 3.09 μg/mL for T. aphylla AE and EE, respectively. T. aphylla AE demonstrated a comparable cytotoxic effect with that offered by the control drug cisplatin (IC50 value of 1.17 ± 0.13 μg/mL), even with higher safety profile against normal fibroblast cells (IC50 values of T. aphylla AE versus cisplatin: 79.99 ± 4.90 versus 9.08 ± 0.29 μg/mL). T. aphylla extracts could be a valuable source for cytotoxic agents with high safety and selective cytotoxicity profiles. Unfortunately, no antiproliferative potential against Caco-2 or Panc-1 cancer cell lines was detected at a concentration less than 30 μg/mL.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential Antiproliferative Activity and Evaluation of Essential Oil Composition of the Aerial Parts of Tamarix aphylla (L.) H.Karst.: A Wild Grown Medicinal Plant in Jordan

Alhourani

Kasabri

Bustanji

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Meanwhile, Nawwar et al had isolated the galloyl glucoses; 2,6-digalloyl glucose and 3,6-digalloyl glucose [ 29 ], and the novel natural polyphenol, 2- O -galloyl-3- O -(3,4,5,6,7-pentahydroxybiphenyl ether-8 a -carboxylic acid-1-carboxyloyl)-4,6-( S )-hexahydroxybiphenoyl-(α/β)- 4 C 1 -glucopyranose, commonly named tamarixellagic acid ( 31 ), together with the known dehydrodigallic and dehydrotrigallic acids ( 32 and 33 ) [ 30 ]. El Ansari et al had also isolated the sulphunated and acylated flavonols; kaempferol-7,4′-dimethyl-ether-3-sulphate and quercetin 3- O -isoferulyl-β-glucuronide from the flowers of this plant [ 31 ]. Traditionally, this plant has been used as a shade tree in horticulture and locally as a fire barrier, since the high salt content of its leaves makes it difficult to burn [ 32 ].…”

Section: Taccaceae and Tamaricaceaementioning

confidence: 99%

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae

Ntie‐Kang

Njume

Malange

et al. 2016

Nat. Prod. Bioprospect.

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Traditional medicinal practices have a profound influence on the daily lives of people living in developing countries, particularly in Africa, since the populations cannot generally afford the cost of Western medicines. We have undertaken to investigate the correlation between the uses of plants in Traditional African medicine and the biological activities of the derived natural products, with the aim to validate the use of traditional medicine in Northern African communities. The literature is covered for the period 1959–2015 and part III of this review series focuses on plant families with names beginning with letters T to Z. The authors have focused on curating data from journals in natural products and phytomedicine. Within each journal home page, a query search based on country name was conducted. All articles “hits” were then verified, one at a time, that the species was harvested within the Northern African geographical regions. The current data partly constitutes the bases for the development of the Northern African natural compounds database. The review discusses 284 plant-based natural compounds from 34 species and 11 families. It was observed that the ethnobotanical uses of less than 40 % of the plant species surveyed correlated with the bioactivities of compounds identified.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-016-0091-9) contains supplementary material, which is available to authorized users.

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“…Many of these species grow on saline soils, tolerating up to 15,000 ppm soluble and can also tolerate alkaline conditions. In view of this fact, the capability of these plants on synthesizing and accumulating sulfate conjugates of flavonols, phenyl propanoids and other phenolics 5 , 6 is thus not all that surprising. Among the 10 Myricaria species, Myricaria germanica DESV, known in English as German false tamarisk or German tamarisk, is growing in temperate regions especially in the Mediterranean area.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic isoferulic acidamide fromMyricaria germanica(Tamaricaceae)

Nawwar¹,

Swilam

Hashim³

et al. 2013

Plant Signaling & Behavior

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Tamgermanitin, a unique N-trans-Isoferuloyltyramine, together with the hitherto unknown polyphenolics, 2,4-di-O-galloyl-(α/β)-glucopyranose and kaempferide 3,7-disulphate have been isolated from the leaf aqueous ethanol extract of the false tamarisk, Myricaria germanica DESV. In addition, 18 known phenolics were also separated and characterized. All structures were elucidated on the basis of detailed analysis of 1D- 1H and 13C NMR, COSY, HSQC, HMBC and HRFTESIMS spectral data. The extract, its chromatographic column fractions and the isolated isoferuloyltyramine, tamgermanetin demonstrated potential cytotoxic effect against three different tumor cell lines, namely liver (Huh-7), breast (MCF-7) and prostate (PC-3). The IC50''s were found to be substantially low with low-resistance possibility. DNA flow-cytometic analysis indicated that column fractions and tamgermanetin enhanced pre-G apoptotic fraction. Both materials showed inhibiting activity against PARP enzyme activity. In conclusion, we report the isolation and identification of a novel compound, tamgermanitin, from the aqueous ethanol extract of Myricaria germanica leaves. Further, different fractions of the extract and tamgermanitin exhibit potent cytotoxic activities which warrant further investigations.

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A sulphated kaempferol 7,4′-dimethyl ether and a quercetin isoferulylglucuronide from the flowers of Tamarix aphylla

Cited by 28 publications

References 4 publications

Potential Antiproliferative Activity and Evaluation of Essential Oil Composition of the Aerial Parts of Tamarix aphylla (L.) H.Karst.: A Wild Grown Medicinal Plant in Jordan

Potential Antiproliferative Activity and Evaluation of Essential Oil Composition of the Aerial Parts of Tamarix aphylla (L.) H.Karst.: A Wild Grown Medicinal Plant in Jordan

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae

Cytotoxic isoferulic acidamide fromMyricaria germanica(Tamaricaceae)

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