A supramolecular polymeric chain in the cobalt(II) complex with diclofenac: synthesis, crystal structure, spectroscopic, thermal and antioxidant activity

Gacki, Michał; Kafarska, Karolina; Wolf, Wojciech M.

doi:10.1080/00958972.2019.1701664

Cited by 10 publications

(13 citation statements)

References 39 publications

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“…This arrangement propagates along the [100] direction, thus leading to a 1-D polymeric structure with a Co1-O5-Co2 repetitive unit ( Figure S1). Similar supramolecular motifs were recently identified and published by us [2].…”

Section: Resultssupporting

confidence: 82%

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most popular pharmaceuticals that have been used against inflammation, pain, and fever over the years [1]. Their therapeutic effect is mainly based on their ability to inhibit the conversion of the arachidonic acid to prostaglandins [2]. Unfortunately, NSAIDs exhibit acute side effects and may cause dyspepsia, nausea, abdominal pain, constipation, headache, dizziness, and rash [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Their therapeutic effect is mainly based on their ability to inhibit the conversion of the arachidonic acid to prostaglandins [2]. Unfortunately, NSAIDs exhibit acute side effects and may cause dyspepsia, nausea, abdominal pain, constipation, headache, dizziness, and rash [2,3]. Additionally, several NSAIDs can be effectively applied in treatments of colon, lung, and breast cancers [4,5] due to their profound chemopreventive and chemosuppressive effects [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity

et al. 2020

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Three metal complexes of mefenamato ligand 1 were synthesized: [Co2(mef)4(EtOH)2(H2O)4]: 2; [Co(mef)2(MeOH)4]∙2MeOH: 3; and [Ni(mef)2(MeOH)4]∙2MeOH: 4. Their compositions and properties were investigated by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Crystal structures were determined by the single crystal X-ray diffraction technique. Additionally, their antioxidant and antimicrobial activity were established, thus proving good/moderate bioactivity against Gram-positive bacteria and yeasts. In the crystal structure of 2, an apical water molecule is shared between two adjacent cobalt(II) ions, resulting in the formation of a polymeric chain extending along the [100] direction. Meanwhile, structures 3 and 4 have strong intermolecular hydrogen bonds with diverse topologies that yield unique quasi-isostructural arrangements. The packing topology is reflected by the Hirshfeld surface analysis of intermolecular contacts.

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Section: Resultssupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity

et al. 2020

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“…In 1952, the first reported studies regarding the biological activity of cobalt complexes examined the toxicity of the optical isomers of [Co(en) 3 ](NO 3 ) 3 (en = ethylenediamine) [ 3 ]. Since then, many cobalt complexes of biological interest have been reported with the majority of them showing antiproliferative [ [4] , [5] , [6] , [7] ], antimicrobial [ [8] , [9] , [10] ], antifungal [ 11 , 12 ], antiviral [ 13 , 14 ], and antioxidant [ [15] , [16] , [17] ] activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural determination, in vitro and in silico biological evaluation of divalent or trivalent cobalt complexes with indomethacin

Perontsis

Geromichalou

Perdih

et al. 2020

Journal of Inorganic Biochemistry

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The interaction of cobalt chloride with the non-steroidal anti-inflammatory drug indomethacin (Hindo) led to the formation of the polymeric complex [Co(indo-O) 2 (H 2 O) 2 (μ-Cl)] n ·n(MeOH·H 2 O) bearing one chlorido bridge between the cobalt atoms. The presence of the nitrogen-donor co-ligands 2,2′-bipyridine (bipy), 2,2′-bipyridylamine (bipyam), 1,10-phenanthroline (phen) or 1 H -imidazole (Himi) resulted in the isolation of complexes [Co 2 (μ-indo-O,O′) 2 (indo-O) 2 (bipy) 2 (μ-H 2 O)]·3.3MeOH, [Co(indo-O,O′) 2 (bipyam)]·0.9MeOH·0.2H 2 O, [Co(indo-O,O′) 2 (phen)] ( 4 ) and [Co(indo-O) 2 (Himi) 2 ] ( 5 ), respectively, where the indomethacin ligands were coordinated in diverse manners. The study of the affinity of the complexes for calf-thymus DNA revealed their intercalation between the DNA-bases. The binding of the complexes to albumins was also examined and the corresponding binding constants and binding subdomain were determined. The free radical scavenging activity of the compounds was evaluated towards 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Molecular modeling calculations may usually provide a molecular basis for the understanding of both the impairment of DNA by its binding with the studied complexes and the ability of these compounds to transportation through serum albumin proteins. This study can provide information for the elucidation of the mechanism of action of the compounds in a molecular level.

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“…It is well recognized that coordination of metal ions with pharmaceutically active substances may improve their activities and profoundly moderate toxicities [ 23 , 24 ]. While numerous metal–NSAIDS complexes were synthesized and thoroughly analyzed [ 25 , 26 , 27 , 28 , 29 ], only a few species with flufenamic acid have been reported, namely cobalt [ 30 ] nickel [ 19 ], copper [ 31 , 32 , 33 , 34 , 35 , 36 ] and zinc [ 14 , 36 , 37 , 38 ] complexes.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Complexes with Flufenamic Acid for Pharmaceutical Applications—A Novel Three-Centered Coordination Polymer of Mn(II) Flufenamate

et al. 2020

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Five complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with non-steroidal anti-inflammatory drug, flufenamic acid were synthesized: (1) [Mn3(fluf)6EtOH)(H2O)]·3EtOH; (2) [Co(fluf)2(EtOH)(H2O)]·H2O; (3) [Ni(fluf)2(EtOH)(H2O)]·H2O; (4) [Cu(fluf)2·H2O]; (5) [Zn(fluf)2·H2O]. All complexes were characterized by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The crystal structure of 1 was determined by the single crystal X-ray diffraction technique. It crystallizes in the triclinic space group P with three independent Mn(II) cations, six coordinated flufenamato ligands augmented with water and ethanol molecules in the inner coordination sphere. In this crystal, manganese atoms are multiplied by symmetry and form infinite, polymeric chains which extend along the [001] dimension. The Hirshfeld Surface analysis revealed changes in interaction assemblies around all metal centers. The antioxidant and antimicrobial activities were established for all complexes and free ligand for comparison. All compounds exhibit good or moderate bioactivity against Gram-positive bacteria and yeasts.

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A supramolecular polymeric chain in the cobalt(II) complex with diclofenac: synthesis, crystal structure, spectroscopic, thermal and antioxidant activity

Cited by 10 publications

References 39 publications

Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity

Quasi-Isostructural Co(II) and Ni(II) Complexes with Mefenamato Ligand: Synthesis, Characterization, and Biological Activity

Synthesis, structural determination, in vitro and in silico biological evaluation of divalent or trivalent cobalt complexes with indomethacin

Transition Metal Complexes with Flufenamic Acid for Pharmaceutical Applications—A Novel Three-Centered Coordination Polymer of Mn(II) Flufenamate

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